Two-Dimensional Tantalum Carbide (MXenes) Composite Nanosheets for Multiple Imaging-Guided Photothermal Tumor Ablation
文献类型：期刊论文
| 作者 | Dai, Chen1; Chen, Yu3; Jing, Xiangxiang2; Xiang, Lihua1; Yang, Dayang2; Lin, Han3; Liu, Zhuang4; Han, Xiaoxia5; Wu, Rong1 |
| 刊名 | ACS Nano
 |
| 出版日期 | 2017 |
| 卷号 | 11期号:12页码:12696-12712 |
| ISSN号 | 19360851 |
| DOI | 10.1021/acsnano.7b07241 |
| 英文摘要 | MXenes, an emerging family of graphene-analogues two-dimensional (2D) materials, have attracted continuous and tremendous attention in many application fields because of their intrinsic physiochemical properties and high performance in versatile applications. In this work, we report on the construction of tantalum carbide (Ta4C3) MXene-based composite nanosheets for multiple imaging-guided photothermal tumor ablation, which has been achieved by rational choice of the composition of MXenes and their surface functionalization. A redox reaction was activated on the surface of tantalum carbide (Ta4C3) MXene for in situ growth of manganese oxide nanoparticles (MnOx/Ta4C3) based on the reducing surface of the nanosheets. The tantalum components of MnOx/Ta4C3acted as the high-performance contrast agents for contrast-enhanced computed tomography, and the integrated MnOxcomponent functionalized as the tumor microenvironment-responsive contrast agents for T1-weighted magnetic resonance imaging. The photothermal-conversion performance of MnOx/Ta4C3composite nanosheets not only has achieved contrast-enhanced photoacoustic imaging, but also realized the significant tumor-growth suppression by photothermal hyperthermia. This work broadens the biomedical applications of MXenes, not only by the fabrication of family members of biocompatible MXenes, but also by the development of functionalization strategies of MXenes for cancer-theranostic applications. © 2017 American Chemical Society. |
| 源URL | [http://ir.sic.ac.cn/handle/331005/25527]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Department of Ultrasound in Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai; 200072, China; 2.Department of Ultrasound, Hainan General Hospital, Haikou; 570311, China; 3.State Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China; 4.Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai; 200032, China; 5.Second Affiliated Hospital, Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing; 400010, China |
| 推荐引用方式 GB/T 7714 | Dai, Chen,Chen, Yu,Jing, Xiangxiang,et al. Two-Dimensional Tantalum Carbide (MXenes) Composite Nanosheets for Multiple Imaging-Guided Photothermal Tumor Ablation[J]. ACS Nano,2017,11(12):12696-12712. |
| APA | Dai, Chen.,Chen, Yu.,Jing, Xiangxiang.,Xiang, Lihua.,Yang, Dayang.,...&Wu, Rong.(2017).Two-Dimensional Tantalum Carbide (MXenes) Composite Nanosheets for Multiple Imaging-Guided Photothermal Tumor Ablation.ACS Nano,11(12),12696-12712. |
| MLA | Dai, Chen,et al."Two-Dimensional Tantalum Carbide (MXenes) Composite Nanosheets for Multiple Imaging-Guided Photothermal Tumor Ablation".ACS Nano 11.12(2017):12696-12712. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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