A Biomarker Characterizing Neurodevelopment with applications in Autism
文献类型：期刊论文
| 作者 | Jose, JV; Wu, D; Nurnberger, JI; Torres, EB |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2018 |
| 卷号 | 8页码:614 |
| 关键词 | SPECTRUM DISORDERS COMPUTATIONAL PSYCHIATRY ARM MOVEMENTS CHILDREN NEUROSCIENCE PHENOTYPE BEHAVIOR RISK |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-017-18902-w |
| 英文摘要 | Despite great advances in neuroscience and genetic studies, our understanding of neurodevelopmental disorders is still quite limited. An important reason is not having objective psychiatric clinical tests. Here we propose a quantitative neurodevelopment assessment by studying natural movement outputs. Movement is central to behaviors: It involves complex coordination, temporal alterations, and precise dynamic controls. We carefully analyzed the continuous movement output data, collected with high definition electromagnetic sensors at millisecond time scales. We unraveled new metrics containing striking physiological information that was unseen neither by using traditional motion assessments nor by naked eye observations. Our putative biomarker leads to precise individualized classifications. It illustrates clear differences between Autism Spectrum Disorder (ASD) subjects from mature typical developing (TD) individuals. It provides an ASD complementary quantitative classification, which closely agrees with the clinicaly assessed functioning levels in the spectrum. It also illustrates TD potential age-related neurodevelopmental trajectories. Applying our movement biomarker to the parents of the ASD individuals studied in the cohort also shows a novel potential familial signature ASD tie. This paper proposes a putative behavioral biomarker to characterize the level of neurodevelopment with high predicting power, as illustrated in ASD subjects as an example. |
| 学科主题 | Science & Technology - Other Topics |
| 语种 | 英语 |
| 源URL | [http://ir.itp.ac.cn/handle/311006/22982]  |
| 专题 | 理论物理研究所_理论物理所1978-2010年知识产出 |
| 作者单位 | 1.[Torres, Elizabeth B.] Rutgers State Univ, Ctr Biomed Imaging & Modeling, Comp Sci Dept, New Brunswick, NJ USA 2.[Nurnberger, John I.] Indiana Univ Sch Med, Inst Psychiat Res, Dept Psychiat, Indianapolis, IN 46202 USA 3.Jose, Jorge V.] Chinese Acad Sci, Inst Theoret Phys, Key Lab Theoret Phys, Beijing, Peoples R China 4.[Jose, Jorge V.] Indiana Univ Sch Med, Dept Cellular & Integrat Physiol, Indianapolis, IN 46202 USA 5.[Wu, Di 6.Jose, Jorge V.] Indiana Univ, Dept Phys, Bloomington, IN 47405 USA 7.[Jose, Jorge V.] Indiana Univ Sch Med, Stark Neurosci Inst, Indianapolis, IN 46202 USA 8.[Torres, Elizabeth B.] Rutgers State Univ, Psychol Dept, New Brunswick, NJ USA 9.[Torres, Elizabeth B.] Rutgers State Univ, Rutgers Ctr Cognit Sci, New Brunswick, NJ USA |
| 推荐引用方式 GB/T 7714 | Jose, JV,Wu, D,Nurnberger, JI,et al. A Biomarker Characterizing Neurodevelopment with applications in Autism[J]. SCIENTIFIC REPORTS,2018,8:614. |
| APA | Jose, JV,Wu, D,Nurnberger, JI,&Torres, EB.(2018).A Biomarker Characterizing Neurodevelopment with applications in Autism.SCIENTIFIC REPORTS,8,614. |
| MLA | Jose, JV,et al."A Biomarker Characterizing Neurodevelopment with applications in Autism".SCIENTIFIC REPORTS 8(2018):614. |
入库方式： OAI收割
来源：理论物理研究所
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