热门
Effects of surface coating on the controlled release of vitamin B, from mesoporous silica tablets
文献类型：期刊论文
| 作者 | Wu, Zhijian ; Jiang, Yan; Kim, Taehoon; Lee, Kangtaek
|
| 刊名 | JOURNAL OF CONTROLLED RELEASE
 |
| 出版日期 | 2007-06-01 |
| 卷号 | 119期号:2页码:215-221 |
| 关键词 | Mesoporous Silica Vitamin B-1 Organosilane Coating Controlled Release |
| 文献子类 | Article |
| 英文摘要 | The controlled release of vitamin B-1 (VB1, thiamine hydrochloride) from mesoporous silica tablets coated with a series of sol-gel coatings was investigated. Tetraethoxysilane (TEOS), n-propyltrietboxysilane (PTES), n-octyltriethoxysilane (OTES), bis(trimethoxysilyl)hexane (TSH), his (triethoxysilyl)octane (TSO), bis (trimethoxysilylpropyl)amine (TSPA), and bis[(3-trimethoxysilyl)propyl]ethylenediamine (TSPED) were used as precursors for the coatings. The effects of organosilane type and concentration, the number of coatings, drying temperature, and release media on VB1 release from the coated mesoporous silica tablets were comprehensively examined. The TSH, TSO, TSPA, and TSPED coatings were found to be more effective in suppression of release than the other coatings. VB1 release decreases with the increase in the number of coatings and drying temperature. It was found that there is an optimal coating solution concentration for the controlled release. In general, more VB1 is released in 0.01 M HCl solution than in 0.05 M phosphate buffer solution at pH 7.4 because of the electrostatic repulsions between the protonated VB1 cations and the positively charged mesoporous silica carrier/coatings. The experimental results show that drug release can be easily controlled by changing the organosilane type and the number of coating. The method used in this study is an effective and flexible way for controlled release due to the high drug loading and the easy control of release rate. (C) 2007 Elsevier B.V. All rights reserved. |
| WOS关键词 | CONTROLLED DRUG-DELIVERY ; IN-VITRO RELEASE ; DOPED HYBRID XEROGELS ; SOL-GEL ; SYNTHESIS PARAMETERS ; DYE ADSORPTION ; PORE STRUCTURE ; CARRIER ; MCM-41 ; PROPERTY |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000247192800009 |
| 源URL | [http://ir.isl.ac.cn/handle/363002/5819]  |
| 专题 | 中国科学院青海盐湖研究所 青海盐湖研究所_青海盐湖研究所知识仓储 青海盐湖研究所_盐湖资源与化学实验室 |
| 作者单位 | 1.Huaqiao Univ, Coll Mat Sci & Engn, Quanzhou 362021, Peoples R China 2.Chinese Acad Sci, Qinghai Inst Salt Lakes, Xining 810008, Peoples R China 3.Yonsei Univ, Dept Chem Engn, Seoul 120749, South Korea |
| 推荐引用方式 GB/T 7714 | Wu, Zhijian,Jiang, Yan,Kim, Taehoon,et al. Effects of surface coating on the controlled release of vitamin B, from mesoporous silica tablets[J]. JOURNAL OF CONTROLLED RELEASE,2007,119(2):215-221. |
| APA | Wu, Zhijian,Jiang, Yan,Kim, Taehoon,&Lee, Kangtaek.(2007).Effects of surface coating on the controlled release of vitamin B, from mesoporous silica tablets.JOURNAL OF CONTROLLED RELEASE,119(2),215-221. |
| MLA | Wu, Zhijian,et al."Effects of surface coating on the controlled release of vitamin B, from mesoporous silica tablets".JOURNAL OF CONTROLLED RELEASE 119.2(2007):215-221. |
入库方式： OAI收割
来源：青海盐湖研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。