Determination of sialic acids in the serum of cancer patients by capillary electrophoresis
文献类型：期刊论文
| 作者 | Dong, XL; Xu, X; Han, F; Ping, XY; Yuang, XL; Lin, BC |
| 刊名 | electrophoresis
 |
| 出版日期 | 2001-07-01 |
| 卷号 | 22期号:11页码:2231-2235 |
| 关键词 | capillary electrophoresis sialic acids cancer patients |
| 英文摘要 | a novel method for the determination of n-acetylneuraminic acid (nana) and n-glycolylneuraminic acid (ngna) was developed by using high-performance capillary electrophoresis (hpce) with uv detection at 195 nm. nana and ngna were separated directly and analyzed without pre- or postcolumn derivation. the detection limit of nana is 9.6 x 10(-6) mol l-1 and for mass 3.879 x 10(-14) mol (39 fmol). this method was applied for the determination of nana in 30 normal human and 72 cancer patients. the results demonstrated that nana in the sera of cancer patients increased significantly as compared with the normal human (p < 0.001). the new method is simple and sensitive, and is suitable for basic research and clinical application to malignant tumors. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | performance liquid-chromatography ; n-glycolylneuraminic acids ; acetylneuraminic acid ; ultraviolet detection ; glycoproteins ; derivatization ; acetyl |
| 收录类别 | ISTP ; SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000170175800016 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/84629]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Dalian Third Minicipal Hosp, Dalian, Peoples R China 3.Dalian Obstet & Gynecol Hosp, Dalian, Peoples R China 4.Dalian Med Univ, Dalian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, XL,Xu, X,Han, F,et al. Determination of sialic acids in the serum of cancer patients by capillary electrophoresis[J]. electrophoresis,2001,22(11):2231-2235. |
| APA | Dong, XL,Xu, X,Han, F,Ping, XY,Yuang, XL,&Lin, BC.(2001).Determination of sialic acids in the serum of cancer patients by capillary electrophoresis.electrophoresis,22(11),2231-2235. |
| MLA | Dong, XL,et al."Determination of sialic acids in the serum of cancer patients by capillary electrophoresis".electrophoresis 22.11(2001):2231-2235. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。