Delivery systems for theranostics in neurodegenerative diseases
文献类型:期刊论文
作者 | Li, Yan1; Liu, Ruiyuan1,2; Ji, Weihong1,2; Li, Yanhui1; Liu, Linying1,2; Zhang, Xin1 |
刊名 | NANO RESEARCH |
出版日期 | 2018-10-01 |
卷号 | 11期号:10页码:5535-5555 |
ISSN号 | 1998-0124 |
关键词 | Neurodegenerative Diseases Theranostics Blood-brain Barrier Delivery Systems |
DOI | 10.1007/s12274-018-2067-z |
英文摘要 | Neurodegenerative diseases are characterized by progressive nervous system dysfunction, which affects over 90,000 people every year. Although numerous contrast agents and therapeutic drugs are available for the diagnosis and therapy of neurodegenerative diseases, there are several limitations to their application. Particularly, these contrast agents and drugs are restricted from entering into the brain because of the blood-brain barrier, which represents a major bottleneck to efficacious and safe theranostics of neurodegenerative diseases. Nanoparticles can offer impressive improvement in the theranostics of neurodegenerative diseases, as they can effectively deliver contrast agents and drugs to target sites in the central nervous system. In this review, we describe various delivery systems, including lipid nanoparticles, polymeric nanoparticles, inorganic nanoparticles, and exosomes useful for the theranostics of neurodegenerative diseases. Finally, we outline current challenges and our perspectives on the development of delivery systems for theranostics of neurodegenerative diseases. |
WOS关键词 | Solid Lipid Nanoparticles ; Blood-brain-barrier ; Dual-functional Nanoparticles ; Beta-amyloid Aggregation ; Alzheimers-disease ; Parkinsons-disease ; Drug-delivery ; Alpha-synuclein ; Sirna Delivery ; Magnetic Nanoparticles |
资助项目 | National High Technology Research and Development Program[2016YFA0200303] ; Beijing Natural Science Foundation[L172046] ; National Natural Science Foundation of China[31522023] ; National Natural Science Foundation of China[51373177] ; National Natural Science Foundation of China[51573188] ; Beijing Municipal Science & Technology Commission[Z161100002616015] ; Chinese Academy of Sciences[XDA09030301-3] |
WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
语种 | 英语 |
出版者 | TSINGHUA UNIV PRESS |
WOS记录号 | WOS:000446423900029 |
资助机构 | National High Technology Research and Development Program ; Beijing Natural Science Foundation ; National Natural Science Foundation of China ; Beijing Municipal Science & Technology Commission ; Chinese Academy of Sciences |
源URL | [http://ir.ipe.ac.cn/handle/122111/26213] |
专题 | 中国科学院过程工程研究所 |
通讯作者 | Zhang, Xin |
作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Yan,Liu, Ruiyuan,Ji, Weihong,et al. Delivery systems for theranostics in neurodegenerative diseases[J]. NANO RESEARCH,2018,11(10):5535-5555. |
APA | Li, Yan,Liu, Ruiyuan,Ji, Weihong,Li, Yanhui,Liu, Linying,&Zhang, Xin.(2018).Delivery systems for theranostics in neurodegenerative diseases.NANO RESEARCH,11(10),5535-5555. |
MLA | Li, Yan,et al."Delivery systems for theranostics in neurodegenerative diseases".NANO RESEARCH 11.10(2018):5535-5555. |
入库方式: OAI收割
来源:过程工程研究所
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