The phenyl linker markedly increases the immunogenicity of the pneumococcal polysaccharide conjugate vaccine
文献类型：期刊论文
| 作者 | Wei, D; Yu, WL; Hu, CY; Shen, LJ; Hu, T; Wei, Dong; Yu, Weili; Hu, Chunyang; Shen, Lijuan; Hu, Tao |
| 刊名 | BIOTECHNOLOGY LETTERS
 |
| 出版日期 | 2018 |
| 卷号 | 40期号:8页码:1263 |
| 关键词 | Capsular polysaccharide PROTEIN Conjugate vaccine IMPROVES Phenyl linker CARRIER Streptococcus pneumoniae DISEASE Tetanus toxoid |
| ISSN号 | 0141-5492 |
| DOI | 10.1007/s10529-018-2575-7 |
| 文献子类 | Article |
| 英文摘要 | Capsular polysaccharide (PS) of Streptococcus pneumoniae is a key virulence factor and typically conjugated with a carrier protein. It is necessary to improve the immunogenicity of the conjugate vaccine against S. pneumoniae. A phenyl linker between tetanus toxoid (TT) and S. pneumoniae Type 14 PS was used to improve the PS-specific immunogenicity of the conjugate vaccine. As compared with the one with the amyl linker (PS-TT), the conjugate with the phenyl linker (PS-phe-TT) decreased the TT-specific IgG titers and significantly increased the PS-specific IgG titers and the IL-5 level. The phenyl linker could potentiate a robust humoral immune response to PS by decreasing the carrier-induced epitopic suppression effect. PS-phe-TT was expected to act as an effective vaccine against S. pneumoniae. |
| WOS记录号 | WOS:000438090800012 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/26696]  |
| 专题 | 中国科学院过程工程研究所 |
| 推荐引用方式 GB/T 7714 | Wei, D,Yu, WL,Hu, CY,et al. The phenyl linker markedly increases the immunogenicity of the pneumococcal polysaccharide conjugate vaccine[J]. BIOTECHNOLOGY LETTERS,2018,40(8):1263, 1270. |
| APA | Wei, D.,Yu, WL.,Hu, CY.,Shen, LJ.,Hu, T.,...&Hu, Tao.(2018).The phenyl linker markedly increases the immunogenicity of the pneumococcal polysaccharide conjugate vaccine.BIOTECHNOLOGY LETTERS,40(8),1263. |
| MLA | Wei, D,et al."The phenyl linker markedly increases the immunogenicity of the pneumococcal polysaccharide conjugate vaccine".BIOTECHNOLOGY LETTERS 40.8(2018):1263. |
入库方式： OAI收割
来源：过程工程研究所
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