The porous spherical LiFePO4 (LFP) nanostructures were synthesized by a spray drying technology, followed by a calcination process. Effect of compacted density on the electrochemical performance of the 18650 cells, which employed as-prepared spherical LFP materials, was investigated systemically. The morphology study and physical characterization results show that the spherical LFP/C are composed of numerous particles with an average size of 300 nm, and have well-developed interconnected pore structure and a specific surface area of 12-15 m(2)/g. For CR2032 coin-type cell, the specific discharge capacity of the LFP/C was 162-164 mAh/g at 0.2C, and the capacity retention can reach up to 100% after 50 cycles at 1 C. For 18650 batteries, the cathode slurry viscosity of the LFP/C with LiOH as lithium source is larger than that with Li2CO3 as lithium source. For the sintering temperature of the LFP material is reduced to 700 degrees C, meanwhile the carbon content is reduced to 1.1%, the compacted density of the LFP material electrode can reach 2.47 g/cm(3).