Lymph Node-Targeting Nanovaccine through Antigen-CpG Self-Assembly Potentiates Cytotoxic T Cell Activation
文献类型：期刊论文
| 作者 | Xi, XB; Zhang, LJ; Lu, GH; Gao, XY; Wei, W; Ma, GH; Xi, Xiaobo; Zhang, Lijun; Lu, Guihong; Gao, Xiaoyong |
| 刊名 | JOURNAL OF IMMUNOLOGY RESEARCH
 |
| 出版日期 | 2018 |
| 关键词 | POLY-DL-LACTIDE-POLY(ETHYLENE GLYCOL) MICROSPHERES DENDRITIC CELLS CROSS-PRESENTATION ANTITUMOR IMMUNITY PROCESS PARAMETERS CANCER VACCINES CUTTING EDGE IN-VIVO CD8(+) NANOPARTICLES |
| ISSN号 | 2314-8861 |
| DOI | 10.1155/2018/3714960 |
| 文献子类 | Article |
| 英文摘要 | Therapeutic vaccines that arouse the cytotoxic T cell immune response to reject infected cells have been investigated extensively for treating disease. Due to the large amounts of resident antigen-presenting cells (APCs) and T cells in lymph nodes, great efforts have been made to explore the strategy of targeting lymph nodes directly with nanovaccines to activate T cells. However, these nanovaccines still have several problems, such as a low loading efficiency and compromised activity of antigens and adjuvants derived from traditional complicated preparation. There are also safety concerns about materials synthesized without FDA approval. Herein, we construct an assembled nanoparticle composed of an antigen (ovalbumin, OVA) and adjuvant (CpG) to ensure its safety and high loading efficiency. The activity of both components was well preserved due to the mild self-assembly process. The small size, narrow distribution, negative charge, and good stability of the nanoparticle endow these nanovaccines with superior capacity for lymph node targeting. Correspondingly, the accumulation at lymph nodes can be improved by 10-fold. Subsequently, due to the sufficient APC internalization and maturation in lymph nodes, similar to 60% of T cells are stimulated to proliferate and over 70% of target cells are specifically killed. Based on the effective and quick cellular immune response, the assembled nanoparticles exhibit great potential as therapeutic vaccines. |
| WOS记录号 | WOS:000437159700001 |
| 资助机构 | National Natural Science Foundation of China [21622608] ; National Key R&D Program of China [2017YFA0207900] ; National Science and Technology Major Projects for "Major New Drug Innovation and Development" [2014ZX09102045-004] ; Beijing Talents Fund [2015000021223ZK20] |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/26820]  |
| 专题 | 中国科学院过程工程研究所 |
| 推荐引用方式 GB/T 7714 | Xi, XB,Zhang, LJ,Lu, GH,et al. Lymph Node-Targeting Nanovaccine through Antigen-CpG Self-Assembly Potentiates Cytotoxic T Cell Activation[J]. JOURNAL OF IMMUNOLOGY RESEARCH,2018. |
| APA | Xi, XB.,Zhang, LJ.,Lu, GH.,Gao, XY.,Wei, W.,...&Ma, Guanghui.(2018).Lymph Node-Targeting Nanovaccine through Antigen-CpG Self-Assembly Potentiates Cytotoxic T Cell Activation.JOURNAL OF IMMUNOLOGY RESEARCH. |
| MLA | Xi, XB,et al."Lymph Node-Targeting Nanovaccine through Antigen-CpG Self-Assembly Potentiates Cytotoxic T Cell Activation".JOURNAL OF IMMUNOLOGY RESEARCH (2018). |
入库方式： OAI收割
来源：过程工程研究所
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