Electrospun Micropatterned Nanocomposites Incorporated with Cu2S Nanoflowers for Skin Tumor Therapy and Wound Healing
文献类型：期刊论文
| 作者 | Wang, Xiaocheng1,2; Lv, Fang3; Li, Tian1,2; Han, Yiming3; Yi, Zhengfang3; Liu, Mingyao3; Chang, Jiang1; Wu, Chengtie1 |
| 刊名 | ACS Nano
 |
| 出版日期 | 2017 |
| 卷号 | 11期号:11页码:11337-11349 |
| ISSN号 | 19360851 |
| DOI | 10.1021/acsnano.7b05858 |
| 英文摘要 | Surgical excision of skin cancers can hardly remove the tumor tissues completely and simultaneously result in cutaneous defects. To avoid tumor recurrence and heal the tumor-induced wounds, we designed a tissue engineering membrane possessing bifunctions of tumor therapy and skin tissue regeneration. The micropatterned nanocomposite membrane was successfully fabricated by incorporating Cu2S nanoflowers into biopolymer fibers via a modified electrospinning method. With uniformly embedded Cu2S nanoparticles, the membranes exhibited excellent and controllable photothermal performance under near-infrared irradiation, which resulted in high mortality (>90%) of skin tumor cells and effectively inhibited tumor growth in mice. Moreover, the membranes supported the adhesion, proliferation, and migration of skin cells as well as significantly stimulated angiogenesis and healed full-thickness skin defects in vivo. This proof-of-concept study offers a facile and reliable strategy for localized skin tumor therapy and tissue regeneration using bifunctional tissue engineering biomaterials, showing great promise for tumor-induced wound healing applications. © 2017 American Chemical Society. |
| 源URL | [http://ir.sic.ac.cn/handle/331005/25902]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai; 200050, China; 2.University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing; 100049, China; 3.Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai; 200241, China |
| 推荐引用方式 GB/T 7714 | Wang, Xiaocheng,Lv, Fang,Li, Tian,et al. Electrospun Micropatterned Nanocomposites Incorporated with Cu2S Nanoflowers for Skin Tumor Therapy and Wound Healing[J]. ACS Nano,2017,11(11):11337-11349. |
| APA | Wang, Xiaocheng.,Lv, Fang.,Li, Tian.,Han, Yiming.,Yi, Zhengfang.,...&Wu, Chengtie.(2017).Electrospun Micropatterned Nanocomposites Incorporated with Cu2S Nanoflowers for Skin Tumor Therapy and Wound Healing.ACS Nano,11(11),11337-11349. |
| MLA | Wang, Xiaocheng,et al."Electrospun Micropatterned Nanocomposites Incorporated with Cu2S Nanoflowers for Skin Tumor Therapy and Wound Healing".ACS Nano 11.11(2017):11337-11349. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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