Osteogenesis Catalyzed by Titanium-Supported Silver Nanoparticles
文献类型：期刊论文
| 作者 | Cao, Huiliang1; Zhang, Wenjie2; Meng, Fanhao1; Guo, Jinshu1; Wang, Donghui1; Qian, Shi1; Jiang, Xinquan2; Liu, Xuanyong1; Chu, Paul K.3 |
| 刊名 | ACS Applied Materials and Interfaces
 |
| 出版日期 | 2017 |
| 卷号 | 9期号:6页码:5149-5157 |
| ISSN号 | 19448244 |
| DOI | 10.1021/acsami.6b15448 |
| 英文摘要 | Silver nanoparticles (Ag NPs) were widely explored for antimicrobial applications, whereas the translation into drugs and implantable antibacterial devices provoked serious concerns about their potential cytotoxicity. Herein, Ag NPs with diameters ranging from 4 to 19 nm were in situ fabricated and immobilized on titanium by using a plasma immersion ion implantation process. The particles have a population-dependent capability in activating the integrin α5 orchestrated MAPK/ERK signal cascade of osteoblast differentiation in rat bone marrow stem cells (BMSCs), and promoting osteointegration of titanium. It was demonstrated that the titanium-supported Ag NPs played an important role in motivating integrin α5 through triggering the galvanic hydrogen evolution reactions, which was found in positive correlation with the distribution density of the immobilized Ag NPs. Since cellular uptake is a key factor determining the cytotoxic performance of Ag NPs, the extracellular effects of immobilized Ag NPs on promoting osteogenesis provided new insights into the safe application of nanomaterials, and into designing and developing renewed antibacterial devices with selective toxicity. © 2017 American Chemical Society. |
| 源URL | [http://ir.sic.ac.cn/handle/331005/25893]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China; 2.Department of Prosthodontics, School of Medicine, Ninth People's Hospital Affiliated, Shanghai Jiao Tong University, 639 Zhizaoju Road, Shanghai; 200011, China; 3.Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong |
| 推荐引用方式 GB/T 7714 | Cao, Huiliang,Zhang, Wenjie,Meng, Fanhao,et al. Osteogenesis Catalyzed by Titanium-Supported Silver Nanoparticles[J]. ACS Applied Materials and Interfaces,2017,9(6):5149-5157. |
| APA | Cao, Huiliang.,Zhang, Wenjie.,Meng, Fanhao.,Guo, Jinshu.,Wang, Donghui.,...&Chu, Paul K..(2017).Osteogenesis Catalyzed by Titanium-Supported Silver Nanoparticles.ACS Applied Materials and Interfaces,9(6),5149-5157. |
| MLA | Cao, Huiliang,et al."Osteogenesis Catalyzed by Titanium-Supported Silver Nanoparticles".ACS Applied Materials and Interfaces 9.6(2017):5149-5157. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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