Metalloporphyrin-encapsulated biodegradable nanosystems for highly efficient magnetic resonance imaging-guided sonodynamic cancer therapy
文献类型：期刊论文
| 作者 | Huang, Ping1; Qian, Xiaoqin3; Chen, Yu2; Yu, Luodan2; Lin, Han2; Wang, Liying2; Zhu, Yufang1; Shi, Jianlin2 |
| 刊名 | Journal of the American Chemical Society
 |
| 出版日期 | 2017 |
| 卷号 | 139期号:3页码:1275-1284 |
| ISSN号 | 00027863 |
| DOI | 10.1021/jacs.6b11846 |
| 英文摘要 | Traditional photodynamic therapy (PDT) suffers from the critical issues of low tissue-penetrating depth of light and potential phototoxicity, which are expected to be solved by developing new dynamic therapy-based therapeutic modalities such as sonodynamic therapy (SDT). In this work, we report on the design/fabrication of a high-performance multifunctional nanoparticulate sonosensitizer for efficient in vivo magnetic resonance imaging (MRI)-guided SDT against cancer. The developed approach takes the structural and compositional features of mesoporous organosilica-based nanosystems for the fabrication of sonosensitizers with intriguing theranostic performance. The welldefined mesoporosity facilitates the high loading of organic sonosensitizers (protoporphyrin, PpDi) and further chelating of paramagnetic transitional metal Mn ions based on metalloporphyrin chemistry (MnPpIX). The mesoporous structure of large surface area also maximizes the accessibility of water molecules to the encapsulated paramagnetic Mn ions, endowing the composite sonosensitizers with markedly high MRI performance (rl= 9.43 mM-1s-2) for SDT guidance and monitoring. Importantly, the developed multifunctional sonosensitizers (HMONs-MnPpIX-PEG) with controllable biodegradation behavior and high biocompatibility show distinctively high SDT efficiency for inducing the cancer-cell death in vitro and suppressing the tumor growth in vivo. This report provides a paradigm that nanotechnology-enhanced SDT based on elaborately designed highperformance multifunctional sonosensitizers will pave a new way for efficient cancer treatment by fully taking the advantages (noninvasiveness, convenience, cost-effectiveness, etc.) of ultrasound therapy and quickly developing nanomedicine. © 2016 American Chemical Society. |
| 源URL | [http://ir.sic.ac.cn/handle/331005/25842]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai; 200093, China; 2.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China; 3.Department of Ultrasound, Affiliated People's Hospital, Jiangsu University, Zhenjiang; 212002, China |
| 推荐引用方式 GB/T 7714 | Huang, Ping,Qian, Xiaoqin,Chen, Yu,et al. Metalloporphyrin-encapsulated biodegradable nanosystems for highly efficient magnetic resonance imaging-guided sonodynamic cancer therapy[J]. Journal of the American Chemical Society,2017,139(3):1275-1284. |
| APA | Huang, Ping.,Qian, Xiaoqin.,Chen, Yu.,Yu, Luodan.,Lin, Han.,...&Shi, Jianlin.(2017).Metalloporphyrin-encapsulated biodegradable nanosystems for highly efficient magnetic resonance imaging-guided sonodynamic cancer therapy.Journal of the American Chemical Society,139(3),1275-1284. |
| MLA | Huang, Ping,et al."Metalloporphyrin-encapsulated biodegradable nanosystems for highly efficient magnetic resonance imaging-guided sonodynamic cancer therapy".Journal of the American Chemical Society 139.3(2017):1275-1284. |
入库方式： OAI收割
来源：上海硅酸盐研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。