Targeting Upconversion Nanoprobes for Magnetic Resonance Imaging of Early Colon Cancer
文献类型：期刊论文
| 作者 | Jin, Yingying1; Ni, Dalong2; Zhang, Jiawen1; Han, Fang1; Wang, Jing1; Gao, Lu1; Zhang, Hua1; Liu, Yanyan2; Cui, Zhaowen2; Yao, Zhenwei1 |
| 刊名 | Particle and Particle Systems Characterization
 |
| 出版日期 | 2017 |
| 卷号 | 34期号:3 |
| ISSN号 | 09340866 |
| DOI | 10.1002/ppsc.201600393 |
| 英文摘要 | Colon cancer (CC) is one of the most common intestinal malignancies and is difficult to detect in its early stage by magnetic resonance imaging (MRI) with currently used contrast agents (CAs). The development of targeted CAs contributes to the early diagnosis of CC and thereby enables early intervention and timely therapy. Considering the outstanding performance of upconversion nanoprobes (UCNPs) in high-performance MR and fluorescence imaging, a new type of nanoprobes with considerably enhanced imaging performance is developed herein. Carcinoembryonic antigen (CEA) antibody is conjugated onto the surface of UCNPs to achieve the targeted imaging of early CC tumors, which overexpress CEA. Both toxicity tests and histological/hematological examinations demonstrate the excellent biocompatibility of these CC-targeting nanoprobes, which possess great potential for clinical application in the early diagnosis of CC. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
| 源URL | [http://ir.sic.ac.cn/handle/331005/25738]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Department of Radiology, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai; 200040, China; 2.State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai; 200050, China; 3.Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai; 200062, China |
| 推荐引用方式 GB/T 7714 | Jin, Yingying,Ni, Dalong,Zhang, Jiawen,et al. Targeting Upconversion Nanoprobes for Magnetic Resonance Imaging of Early Colon Cancer[J]. Particle and Particle Systems Characterization,2017,34(3). |
| APA | Jin, Yingying.,Ni, Dalong.,Zhang, Jiawen.,Han, Fang.,Wang, Jing.,...&Bu, Wenbo.(2017).Targeting Upconversion Nanoprobes for Magnetic Resonance Imaging of Early Colon Cancer.Particle and Particle Systems Characterization,34(3). |
| MLA | Jin, Yingying,et al."Targeting Upconversion Nanoprobes for Magnetic Resonance Imaging of Early Colon Cancer".Particle and Particle Systems Characterization 34.3(2017). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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