Enhanced anti-infective efficacy of zno nanoreservoirs through a combination of intrinsic anti-biofilm activity and reinforced innate defense
文献类型：期刊论文
| 作者 | Wang, Jiaxing1; Zhou, Huaijuan2; Guo, Geyong1; Tan, Jiaqi1; Wang, Qiaojie1; Tang, Jin5; Liu, Wei1; Shen, Hao1; Li, Jinhua2,3,4; Zhang, Xianlong1 |
| 刊名 | ACS Applied Materials and Interfaces
 |
| 出版日期 | 2017 |
| 卷号 | 9期号:39页码:33609-33623 |
| ISSN号 | 19448244 |
| DOI | 10.1021/acsami.7b08864 |
| 英文摘要 | The increasing prevalence of implant-associated infections (IAIs) imposes a heavy burden on patients and medical providers. Bacterial biofilms are recalcitrant to antiseptic drugs and local immune defense and can attenuate host proinflammatory response to interfere with bacterial clearance. Zinc oxide nanoparticles (ZnO NPs) play a dual role in antibacterial and immunomodulatory activities but compromise the cytocompatibility because of their intracellular uptake. Here, ZnO NPs were immobilized on titanium to form homogeneous nanofilms (from discontinuous to continuous) through magnetron sputtering, and the possible antimicrobial activity and immunomodulatory effect of nano-ZnO films were investigated. Nano-ZnO films were found to prohibit sessile bacteria more than planktonic bacteria in vitro, and the antibacterial effect occurred in a dose-dependent manner. Using a novel mouse soft tissue IAI model, the in vivo results revealed that nano-ZnO films possessed outstanding antimicrobial efficacy, which could not be ascribed solely to the intrinsic anti-infective activity of nano-ZnO films observed in vitro. Macrophages and polymorphonuclear leukocytes (PMNs), two important factors in innate immune response, were cocultured with nano-ZnO and bacteria/lipopolysaccharide in vitro, and the nano-ZnO films could enhance the antimicrobial efficacy of macrophages and PMNs through promoting phagocytosis and secretion of inflammatory cytokines. This study provides insights into the anti-infective activity and mechanism of ZnO and consolidates the theoretical basis for future clinical applications of ZnO. © 2017 American Chemical Society. |
| 源URL | [http://ir.sic.ac.cn/handle/331005/25714]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Department of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai; 200233, China; 2.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China; 3.Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong; 999077, Hong Kong; 4.University of Chinese Academy of Sciences, Beijing; 100049, China; 5.Department of Clinical Laboratory, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai; 200233, China |
| 推荐引用方式 GB/T 7714 | Wang, Jiaxing,Zhou, Huaijuan,Guo, Geyong,et al. Enhanced anti-infective efficacy of zno nanoreservoirs through a combination of intrinsic anti-biofilm activity and reinforced innate defense[J]. ACS Applied Materials and Interfaces,2017,9(39):33609-33623. |
| APA | Wang, Jiaxing.,Zhou, Huaijuan.,Guo, Geyong.,Tan, Jiaqi.,Wang, Qiaojie.,...&Zhang, Xianlong.(2017).Enhanced anti-infective efficacy of zno nanoreservoirs through a combination of intrinsic anti-biofilm activity and reinforced innate defense.ACS Applied Materials and Interfaces,9(39),33609-33623. |
| MLA | Wang, Jiaxing,et al."Enhanced anti-infective efficacy of zno nanoreservoirs through a combination of intrinsic anti-biofilm activity and reinforced innate defense".ACS Applied Materials and Interfaces 9.39(2017):33609-33623. |
入库方式： OAI收割
来源：上海硅酸盐研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。