A 3D-printed scaffold with MoS2 nanosheets for tumor therapy and tissue regeneration
文献类型：期刊论文
| 作者 | Wang, Xiaocheng1,2; Li, Tao3; Ma, Hongshi1; Zhai, Dong1; Jiang, Chuan3; Chang, Jiang1; Wang, Jinwu3; Wu, Chengtie1 |
| 刊名 | NPG Asia Materials
 |
| 出版日期 | 2017 |
| 卷号 | 9期号:4 |
| ISSN号 | 18844049 |
| DOI | 10.1038/am.2017.47 |
| 英文摘要 | The treatment of malignant bone tumors is a significant clinical challenge because it requires the simultaneous removal of tumor tissues and regeneration of bone defects, and bifunctional three-dimensional (3D) scaffolds that function in both tumor therapy and tissue regeneration are expected to address this need. In this study, novel bifunctional scaffolds (MS-AKT scaffolds) were successfully fabricated by combining a 3D printing technique with a hydrothermal method. During the hydrothermal process, MoS2 nanosheets were grown in situ on the strut surface of bioceramic scaffolds, endowing them with photothermal therapeutic potential. Under near-infrared (NIR) irradiation, the temperature of the MS-AKT scaffolds rapidly increased and was effectively modulated by varying the MoS2 content, scaffold sizes and laser power densities. The photothermal temperature significantly decreased the viability of osteosarcoma cells and breast cancer cells and inhibited tumor growth in vivo. Moreover, the MS-AKT scaffolds supported the attachment, proliferation and osteogenic differentiation of bone mesenchymal stem cells and induced bone regeneration in vivo. This bifunctional scaffold, which treats the tumor and facilitates bone growth, offers a promising clinical strategy to treat tumor-induced bone defects. This proof-of-concept study demonstrates the feasibility of localized tumor therapy and tissue regeneration in diverse tissue engineering applications using multifunctional biomaterials. © The Author(s) 2017. |
| 源URL | [http://ir.sic.ac.cn/handle/331005/25710]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai; 200050, China; 2.University of Chinese Academy of Sciences, Beijing, China; 3.Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital Affiliated Shanghai Jiao Tong, University School of Medicine, 639 Zhizaoju Road, Shanghai; 200011, China |
| 推荐引用方式 GB/T 7714 | Wang, Xiaocheng,Li, Tao,Ma, Hongshi,et al. A 3D-printed scaffold with MoS2 nanosheets for tumor therapy and tissue regeneration[J]. NPG Asia Materials,2017,9(4). |
| APA | Wang, Xiaocheng.,Li, Tao.,Ma, Hongshi.,Zhai, Dong.,Jiang, Chuan.,...&Wu, Chengtie.(2017).A 3D-printed scaffold with MoS2 nanosheets for tumor therapy and tissue regeneration.NPG Asia Materials,9(4). |
| MLA | Wang, Xiaocheng,et al."A 3D-printed scaffold with MoS2 nanosheets for tumor therapy and tissue regeneration".NPG Asia Materials 9.4(2017). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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