Near infrared-assisted Fenton reaction for tumor-specific and mitochondrial DNA-targeted photochemotherapy
文献类型：期刊论文
| 作者 | Hu, Ping1; Wu, Tong3; Fan, Wenpei1; Chen, Lei4; Liu, Yanyan1; Ni, Dalong2; Bu, Wenbo2; Shi, Jianlin1 |
| 刊名 | Biomaterials
 |
| 出版日期 | 2017 |
| 卷号 | 141页码:86-95 |
| ISSN号 | 01429612 |
| DOI | 10.1016/j.biomaterials.2017.06.035 |
| 英文摘要 | The strong dependence on oxygen level, low ultraviolet/visible (UV/vis) light penetration depth and the extremely short lifetime of reactive oxygen species (ROS) are the major challenges of photodynamic therapy (PDT) for tumors. Fenton reaction can produce abundant ROS such as reactive hydroxyl radicals ([rad]OH) with significantly higher oxidation performance than singlet oxygen (1O2), which, however, has been rarely used in biomedical fields due to strict reaction conditions (favorably in pH range of 3–4, mostly under UV/vis light catalysis). Herein we propose and demonstrate a photochemotherapy (PCT) strategy of cancer therapy using near-infrared (NIR)-assisted tumor-specific Fenton reactions. NIR light-upconverted UV/vis light by upconversion nanoparticles (UCNPs) catalyze the intra-mitochondrial Fenton reaction between the delivered Fe2+and H2O2species over-expressed in cancer cell's mitochondria to in-situ kill the cancer cells. The intra-mitochondrial ROS generation of enabled by directly targeting the mitochondrial DNA (mtDNA) helix minimized the distance between the ROS and mtDNA molecules, thus the present PCT strategy showed much enhanced and tumor-specific therapeutic efficacy, as demonstrated by the intratumoral-accelerated [rad]OH burst and elevated cytotoxicity. Following the direct intratumoral injection, the PCT revealed marked tumor regression effect in vivo. This constructed PCT-agent is the first paradigm of NIR-upconversion catalyzed intra-mitochondrial Fenton reaction in response to tumoral microenvironment, establishing a novel photochemotherapy strategy for efficient cancer therapy. © 2017 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/25656]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China; 2.Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai; 200062, China; 3.Department of Materials Science and Engineering, Stanford University, Stanford; CA; 94305, United States; 4.Department of Chemistry and Laboratory of Advanced Materials, State Key Laboratory of Molecular Engineering of Polymers, Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai; 200433, China |
| 推荐引用方式 GB/T 7714 | Hu, Ping,Wu, Tong,Fan, Wenpei,et al. Near infrared-assisted Fenton reaction for tumor-specific and mitochondrial DNA-targeted photochemotherapy[J]. Biomaterials,2017,141:86-95. |
| APA | Hu, Ping.,Wu, Tong.,Fan, Wenpei.,Chen, Lei.,Liu, Yanyan.,...&Shi, Jianlin.(2017).Near infrared-assisted Fenton reaction for tumor-specific and mitochondrial DNA-targeted photochemotherapy.Biomaterials,141,86-95. |
| MLA | Hu, Ping,et al."Near infrared-assisted Fenton reaction for tumor-specific and mitochondrial DNA-targeted photochemotherapy".Biomaterials 141(2017):86-95. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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