Symmetry-breaking assembled porous calcite microspheres and their multiple dental applications
文献类型：期刊论文
| 作者 | Ma, Ming1; Yan, Yanhong2; Qi, Chao1; Qi, Shengcai3; Chern, Shixiong1; Shang, Guangwei3; Wang, Raorao3; Chen, Hangrong1 |
| 刊名 | Science China Materials
 |
| 出版日期 | 2017 |
| 卷号 | 60期号:6页码:516-528 |
| ISSN号 | 20958226 |
| DOI | 10.1007/s40843-017-9038-5 |
| 英文摘要 | Biomedical applications of porous calcium carbonate (CaCO3) microspheres have been mainly restricted by their aqueous instability and low remineralization rate. To overcome these obstacles, a novel symmetry-breaking assembled porous calcite microsphere (PCMS) was constructed in an ethanol/water mixed system using a two-step vapor-diffusion/aging crystallization strategy. In contrast to the conventional additive-induced crystallization method, the present strategy was performed under mild conditions and was free from any foreign additives, thus avoiding the potential contamination of the final product. Meanwhile, the prepared PCMSs were characterized by their highly uniform spherical morphology and large open pores, which are favorable for large protein delivery. An antimicrobial study of immunoglobulin Y (IgY)-loaded PCMSs revealed excellent antimicrobial activity against Streptococcus mutans. More importantly, they showed surprisingly rapid transformation to bone minerals in physiological medium. Evaluation of the in vitro efficacy of PCMSs in dentinal tubule occlusion demonstrated their powerful potential to serve as a catalyst in the repair of dental hard tissue. Therefore, the developed PCMSs show great promise as multifunctional biomaterials for dental treatment applications. © 2017, Science China Press and Springer-Verlag GmbH Germany. |
| 源URL | [http://ir.sic.ac.cn/handle/331005/25618]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.State Key Lab of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China; 2.Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Department of Pediatric Dentistry, School of Stomatology, Tongji University, Shanghai; 200072, China; 3.Department of Stomatology, Shanghai Tenth People’s Hospital, Tongji University, Shanghai; 200072, China |
| 推荐引用方式 GB/T 7714 | Ma, Ming,Yan, Yanhong,Qi, Chao,et al. Symmetry-breaking assembled porous calcite microspheres and their multiple dental applications[J]. Science China Materials,2017,60(6):516-528. |
| APA | Ma, Ming.,Yan, Yanhong.,Qi, Chao.,Qi, Shengcai.,Chern, Shixiong.,...&Chen, Hangrong.(2017).Symmetry-breaking assembled porous calcite microspheres and their multiple dental applications.Science China Materials,60(6),516-528. |
| MLA | Ma, Ming,et al."Symmetry-breaking assembled porous calcite microspheres and their multiple dental applications".Science China Materials 60.6(2017):516-528. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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