Optimal Zn-Modified Ca-Si-Based Ceramic Nanocoating with Zn Ion Release for Osteoblast Promotion and Osteoclast Inhibition in Bone Tissue Engineering
文献类型：期刊论文
| 作者 | Yu, Jiangming1,2; Xu, Lizhang1; Xie, Ning1; Li, Kai3; Xi, Yanhai1; Liu, Xiling1; Zheng, Xuebin3; Chen, Xiongsheng1; Ye, Xiaojian1; Wei, Daixu4 |
| 刊名 | Journal of Nanomaterials
 |
| 出版日期 | 2017 |
| 卷号 | 2017 |
| ISSN号 | 16874110 |
| DOI | 10.1155/2017/7374510 |
| 英文摘要 | We investigated the slow release of Zn ion (Zn2+) from nanocoatings and compared the in vitro response of osteoblasts (MC3T3-E1) and proosteoclasts (RAW 264.7) cultured on Ca2ZnSi2O7nanocoated with different Zn/Ca molar ratios on a Ti-6Al-4V (i.e., Ti) substrate to optimize cell behaviors and molecule levels. Significant morphology differences were observed among samples. By comparing with pure Ti and CaSiO3nanocoating, the morphology of Ca2ZnSi2O7ceramic nanocoatings was rough and contained small nanoparticles or aggregations. Slow Zn2+release from nanocoatings was observed and Zn2+concentration was regulated by varying the Zn/Ca ratios. The cell-response results showed Ca2ZnSi2O7nanocoating at different Zn/Ca molar ratios for osteoblasts and osteoclasts. Compared to other nanocoatings and Ti, sample Zn/Ca (0.3) showed the highest cell viability and upregulated expression of the osteogenic differentiation genes ALP, COL-1, and OCN. Additionally, sample Zn/Ca (0.3) showed the greatest inhibition of RAW 264.7 cell growth and decreased the mRNA levels of osteoclast-related genes OAR, TRAP, and HYA1. Therefore, the optimal Zn-Ca ratio of 0.3 in Ca2ZnSi2O7ceramic nanocoating on Ti had a dual osteoblast-promoting and osteoclast-inhibiting effect to dynamically balance osteoblasts/osteoclasts. These optimal Zn-Ca ratios are valuable for Ca2ZnSi2O7ceramic nanocoating on Ti-coated implants for potential applications in bone tissue regeneration. © 2017 Jiangming Yu et al. |
| 源URL | [http://ir.sic.ac.cn/handle/331005/25578]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Department of Orthopaedics, Changzheng Hospital, Second Military Medical University, Shanghai; 200003, China; 2.National Engineering Research Center for Nanotechnology, Shanghai; 200241, China; 3.Key Laboratory of Inorganic Coating Materials, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200003, China; 4.Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing; 100084, China |
| 推荐引用方式 GB/T 7714 | Yu, Jiangming,Xu, Lizhang,Xie, Ning,et al. Optimal Zn-Modified Ca-Si-Based Ceramic Nanocoating with Zn Ion Release for Osteoblast Promotion and Osteoclast Inhibition in Bone Tissue Engineering[J]. Journal of Nanomaterials,2017,2017. |
| APA | Yu, Jiangming.,Xu, Lizhang.,Xie, Ning.,Li, Kai.,Xi, Yanhai.,...&Wei, Daixu.(2017).Optimal Zn-Modified Ca-Si-Based Ceramic Nanocoating with Zn Ion Release for Osteoblast Promotion and Osteoclast Inhibition in Bone Tissue Engineering.Journal of Nanomaterials,2017. |
| MLA | Yu, Jiangming,et al."Optimal Zn-Modified Ca-Si-Based Ceramic Nanocoating with Zn Ion Release for Osteoblast Promotion and Osteoclast Inhibition in Bone Tissue Engineering".Journal of Nanomaterials 2017(2017). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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