Design, Synthesis of N-phenethyl Cinnamide Derivatives and Their Biological Activities for the Treatment of Alzheimer’s Disease: Antioxidant, Beta-amyloid Disaggregating and Rescue Effects on Memory l
文献类型：期刊论文
| 作者 | Tian Chai1; Xiao-Bo Zhao2; Wei-Feng Wang2; Yin Qiang1; Xiao-Yun Zhang1; Jun-Li Yang2
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| 刊名 | Molecules
 |
| 出版日期 | 2018 |
| 卷号 | 23期号:10页码:2663 |
| 关键词 | Alzheimer’s Disease Gx-50 Dpph Assay Tht Assay Transgenic Drosophila Model Assay |
| DOI | 10.3390/molecules23102663 |
| 英文摘要 | Gx-50 is a bioactive compound for the treatment of Alzheimer’s disease (AD) found in Sichuan pepper (Zanthoxylum bungeanum). In order to find a stronger anti-AD lead compound, 20 gx-50 (1–20) analogs have been designed and synthesized, and their molecular structures were determined based on nuclear magnetic resonance (NMR) and mass spectrometry (MS) analysis, as well as comparison with literature data. Compounds 1–20 were evaluated for their anti-AD potential by using DPPH radical scavenging assay for considering their anti-oxidant activity, thioflavin T (ThT) fluorescence assay for considering the inhibitory or disaggregate potency of Aβ, and transgenic Drosophila model assay for evaluating their rescue effect on memory loss. Finally, compound 13 was determined as a promising anti-AD candidate. |
| 语种 | 英语 |
| 源URL | [http://210.77.64.217/handle/362003/24247]  |
| 专题 | 兰州化学物理研究所_中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| 通讯作者 | Jun-Li Yang |
| 作者单位 | 1.Lanzhou University 2.Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences (CAS) |
| 推荐引用方式 GB/T 7714 | Tian Chai,Xiao-Bo Zhao,Wei-Feng Wang,et al. Design, Synthesis of N-phenethyl Cinnamide Derivatives and Their Biological Activities for the Treatment of Alzheimer’s Disease: Antioxidant, Beta-amyloid Disaggregating and Rescue Effects on Memory l[J]. Molecules,2018,23(10):2663. |
| APA | Tian Chai,Xiao-Bo Zhao,Wei-Feng Wang,Yin Qiang,Xiao-Yun Zhang,&Jun-Li Yang.(2018).Design, Synthesis of N-phenethyl Cinnamide Derivatives and Their Biological Activities for the Treatment of Alzheimer’s Disease: Antioxidant, Beta-amyloid Disaggregating and Rescue Effects on Memory l.Molecules,23(10),2663. |
| MLA | Tian Chai,et al."Design, Synthesis of N-phenethyl Cinnamide Derivatives and Their Biological Activities for the Treatment of Alzheimer’s Disease: Antioxidant, Beta-amyloid Disaggregating and Rescue Effects on Memory l".Molecules 23.10(2018):2663. |
入库方式： OAI收割
来源：兰州化学物理研究所
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