Alternative splicing of the FMR1 gene in human tissues of fetal and adult
文献类型：期刊论文
| 作者 | Kan, D; Li, LY; Fan, Y; Xu, Q; Han, FT; Zhu, NN; Liu, EL; Lin, BC; Wu, GY; Shen, Y |
| 刊名 | progress in natural science
 |
| 出版日期 | 1999-05-01 |
| 卷号 | 9期号:5页码:367-373 |
| 关键词 | FMR1 transcription alternative splicing capillary electrophoresis |
| 英文摘要 | to study the time- and tissue-specificity of alternative splicing of the fmr1 gene, we analyzed the alternative splicing pattern of the fmr1 gene in human tissues from adult and fetus using rt-pcr coupled with capillary electrophoresis. seven alternative splicing variants of fmr1 were found in adult liver and lung. the major three alternative splicing variants of the fmr1 gene in all analyzed fetal tissues were same, though the number of minor isoforms and the relative abundance of major isoforms were different. the major difference of the alternative splicing pat tem between adult and fetus was in exon 12 and 17. the results suggest that the alternative splicing pattern of the fmr1 gene is non-tissue-specific in the same developmental stage and a developmental switch may be present. |
| WOS标题词 | science & technology ; technology |
| 类目[WOS] | materials science, multidisciplinary ; multidisciplinary sciences |
| 研究领域[WOS] | materials science ; science & technology - other topics |
| 关键词[WOS] | fragile-x syndrome ; mental-retardation protein ; capillary electrophoresis ; rna-binding ; kh domains ; localization ; expression ; brain |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000080568900007 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/86199]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Med Sci, Peking Union Med Coll, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing 100005, Peoples R China 2.Tianjin Med Univ, Inst Endocrinol, Tianjin 300070, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Kan, D,Li, LY,Fan, Y,et al. Alternative splicing of the FMR1 gene in human tissues of fetal and adult[J]. progress in natural science,1999,9(5):367-373. |
| APA | Kan, D.,Li, LY.,Fan, Y.,Xu, Q.,Han, FT.,...&Shen, Y.(1999).Alternative splicing of the FMR1 gene in human tissues of fetal and adult.progress in natural science,9(5),367-373. |
| MLA | Kan, D,et al."Alternative splicing of the FMR1 gene in human tissues of fetal and adult".progress in natural science 9.5(1999):367-373. |
入库方式： OAI收割
来源：大连化学物理研究所
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