Optimization and parameter study for chiral separation by capillary electrophoresis
文献类型：期刊论文
| 作者 | Zhu, XF; Lin, BC; Jakob, A; Epperlein, U; Koppenhoefer, B |
| 刊名 | hrc-journal of high resolution chromatography
 |
| 出版日期 | 1999-08-01 |
| 卷号 | 22期号:8页码:449-453 |
| 关键词 | capillary electrophoresis experimental design cyclodextrin chiral separation |
| 英文摘要 | orthogonal design and uniform design were used for the optimization of separation of enantiomers using 2,6-di-o-methyl-beta-cyclodextrin (dm-beta-cd) as a chiral selector by capillary zone electrophoresis, the concentration of dm-beta-cd, buffer ph, running voltage, and capillary temperature were selected as variable parameters, their different effects on peak resolution were studied by the design methods. it was concluded that orthogonal design offers a rapid and efficient means for testing the importance of individual parameters and for determining the optimum operating conditions. however, for a large number of both factors and levels, uniform design is more efficient, the effect of addition of methanol and citric acid buffer on the separation of enantiomers was also examined. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, analytical |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | micellar electrokinetic chromatography ; performance liquid-chromatography ; zone electrophoresis ; amino-acids ; cyclodextrins ; design ; phase ; enantiomers ; resolution ; drugs |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000083356000004 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/86221]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Beijing 100864, Peoples R China 2.Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany |
| 推荐引用方式 GB/T 7714 | Zhu, XF,Lin, BC,Jakob, A,et al. Optimization and parameter study for chiral separation by capillary electrophoresis[J]. hrc-journal of high resolution chromatography,1999,22(8):449-453. |
| APA | Zhu, XF,Lin, BC,Jakob, A,Epperlein, U,&Koppenhoefer, B.(1999).Optimization and parameter study for chiral separation by capillary electrophoresis.hrc-journal of high resolution chromatography,22(8),449-453. |
| MLA | Zhu, XF,et al."Optimization and parameter study for chiral separation by capillary electrophoresis".hrc-journal of high resolution chromatography 22.8(1999):449-453. |
入库方式： OAI收割
来源：大连化学物理研究所
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