Application of liquid pre-column capillary electrophoresis technique to the study of interaction between drug enantiomers and human serum albumin
文献类型：期刊论文
| 作者 | Ding, YS; Zhu, XF; Lin, BC |
| 刊名 | science in china series b-chemistry
 |
| 出版日期 | 1999-12-01 |
| 卷号 | 42期号:6页码:617-623 |
| 关键词 | capillary electrophoresis liquid pre-column binding constant chiral drug human serum albumin |
| 英文摘要 | based on the chiral separation of several basic drugs, dimetindene, tetryzoline, theodrenaline and verapamil, the liquid pre-column capillary electrophoresis (lpc-ce) technique was established. it was used to determine free concentrations of drug enantiomers in mixed solutions with human serum albumin (hsa). to prevent hsa entering the ce chiral separation zone, the mobility differences between hsa and drugs under a specific ph condition were employed in the lpc. thus, the detection confusion caused by protein was totally avoided. further study of binding constants determination and protein binding competitions was carried out. the study proves that the lpc technique could be used for complex media, particularly the matrix of protein coexisting with a variety of drugs. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, multidisciplinary |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | binding constants ; protein-binding ; vancomycin ; peptides |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000084653800009 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/86229]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Dalian Maritime Univ, Dalian 116026, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ding, YS,Zhu, XF,Lin, BC. Application of liquid pre-column capillary electrophoresis technique to the study of interaction between drug enantiomers and human serum albumin[J]. science in china series b-chemistry,1999,42(6):617-623. |
| APA | Ding, YS,Zhu, XF,&Lin, BC.(1999).Application of liquid pre-column capillary electrophoresis technique to the study of interaction between drug enantiomers and human serum albumin.science in china series b-chemistry,42(6),617-623. |
| MLA | Ding, YS,et al."Application of liquid pre-column capillary electrophoresis technique to the study of interaction between drug enantiomers and human serum albumin".science in china series b-chemistry 42.6(1999):617-623. |
入库方式： OAI收割
来源：大连化学物理研究所
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