Reversed-phase high-performance liquid chromatographic investigation of urinary normal and modified nucleosides of cancer patients
文献类型：期刊论文
| 作者 | Xu, G; Di Stefano, C; Liebich, HM; Zhang, Y; Lu, P |
| 刊名 | journal of chromatography b
 |
| 出版日期 | 1999-09-24 |
| 卷号 | 732期号:2页码:307-313 |
| 关键词 | pattern recognition nucleosides |
| 英文摘要 | post-transcriptional modifications in rna give rise to free modified ribonucleosides circulating in the blood stream and excreted in urine. due to their abnormal levels in conjunction with several tumor diseases, they have been suggested as possible tumor markers. the developed rp-hplc method has been applied to analyze the urinary nucleosides in 34 urinary samples from 15 kinds of cancer patients. the statistical analyses showed the urinary nucleoside excretion, especially modified nucleoside levels, in cancer patients were significantly higher than those in normal healthy volunteers. factor analysis was used to classify the patients with cancer and normal healthy humans. it was found that using 15 urinary nucleoside levels or only five modified nucleoside levels as data vectors the factor analysis plot displayed two almost separate clusters representing each group. (c) 1999 elsevier science b.v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | tumor-marker ; capillary electrophoresis ; rna turnover ; excretion ; pseudouridine ; quantitation ; carcinoma ; leukemia ; lung |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000082839700006 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/86241]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China 2.Univ Tubingen, Med Klin, D-72076 Tubingen, Germany |
| 推荐引用方式 GB/T 7714 | Xu, G,Di Stefano, C,Liebich, HM,et al. Reversed-phase high-performance liquid chromatographic investigation of urinary normal and modified nucleosides of cancer patients[J]. journal of chromatography b,1999,732(2):307-313. |
| APA | Xu, G,Di Stefano, C,Liebich, HM,Zhang, Y,&Lu, P.(1999).Reversed-phase high-performance liquid chromatographic investigation of urinary normal and modified nucleosides of cancer patients.journal of chromatography b,732(2),307-313. |
| MLA | Xu, G,et al."Reversed-phase high-performance liquid chromatographic investigation of urinary normal and modified nucleosides of cancer patients".journal of chromatography b 732.2(1999):307-313. |
入库方式： OAI收割
来源：大连化学物理研究所
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