Mass spectrometry based translational proteomics for biomarker discovery and application in colorectal cancer
文献类型：期刊论文
| 作者 | Ma, Hong1,2; Chen, Guilin1,3; Guo, Mingquan1 |
| 刊名 | PROTEOMICS CLINICAL APPLICATIONS
 |
| 出版日期 | 2016-04-01 |
| 卷号 | 10期号:4页码:503-515 |
| 关键词 | Biomarker Colorectal cancer MS MRM Translational proteomics |
| ISSN号 | 1862-8346 |
| DOI | 10.1002/prca.201500082 |
| 英文摘要 | Colorectal cancer (CRC) is a leading cause of cancer-related death in the world. Clinically, early detection of the disease is the most effective approach to tackle this tough challenge. Discovery and development of reliable and effective diagnostic tools for the assessment of prognosis and prediction of response to drug therapy are urgently needed for personalized therapies and better treatment outcomes. Among many ongoing efforts in search for potential CRC biomarkers, MS-based translational proteomics provides a unique opportunity for the discovery and application of protein biomarkers toward better CRC early detection and treatment. This review updates most recent studies that use preclinical models and clinical materials for the identification of CRC-related protein markers. Some new advances in the development of CRC protein markers such as CRC stem cell related protein markers, SRM/MRM-MS and MS cytometry approaches are also discussed in order to address future directions and challenges from bench translational research to bedside clinical application of CRC biomarkers. |
| 资助项目 | Sino-Africa Joint Research Center project[SAJC201328] ; Chinese Academy of Sciences[29Y429291a0129] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000373947200017 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/91]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Guo, Mingquan |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Bot Garden, Sino Africa Joint Res Ctr, Key Lab Plant Germplasm Enhancement & Specialty A, Wuhan, Peoples R China 2.Childrens Hosp Los Angeles, Haematol & Oncol Div, Los Angeles, CA USA 3.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Hong,Chen, Guilin,Guo, Mingquan. Mass spectrometry based translational proteomics for biomarker discovery and application in colorectal cancer[J]. PROTEOMICS CLINICAL APPLICATIONS,2016,10(4):503-515. |
| APA | Ma, Hong,Chen, Guilin,&Guo, Mingquan.(2016).Mass spectrometry based translational proteomics for biomarker discovery and application in colorectal cancer.PROTEOMICS CLINICAL APPLICATIONS,10(4),503-515. |
| MLA | Ma, Hong,et al."Mass spectrometry based translational proteomics for biomarker discovery and application in colorectal cancer".PROTEOMICS CLINICAL APPLICATIONS 10.4(2016):503-515. |
入库方式： OAI收割
来源：武汉植物园
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