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A New Geldanamycin Analogue from Streptomyces hygroscopicus

文献类型：期刊论文

作者Zhang, Hao2; Sun, Guang-Zhi3; Li, Xiang1; Pan, Hong-Yu1; Zhang, Yan-Sheng4
刊名MOLECULES
出版日期2010-03-01
卷号15期号:3页码:1161-1167
关键词Streptomyces hygroscopicus 11-methoxy-17-formyl-17-demethoxy-18-O-21-O-dihydrogeldanamycin geldanamycin
ISSN号1420-3049
DOI10.3390/molecules15031161
英文摘要A new geldanamycin analogue was isolated from Streptomyces hygroscopicus A070101. The structure was elucidated as 11-methoxy-17-formyl-17-demethoxy-18-O-21-O- dihydrogeldanamycin (1) on the basis of extensive 1D and 2D NMR as well as HRESIMS spectroscopic data analysis. Compound 1 showed considerable cytotoxicity (SRB) against human cancer cell lines (breast cancer MCF-7, skin melanoma SK-MEL-2 and lung carcinoma COR-L23).
资助项目National Natural Science Foundation of China[30971885] ; Major Program of Transgenic Species Development of Ministry of Agriculture of China[2009ZX08009-062B] ; National Science & Technology Pillar Program[2009BADB3B05]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000275956900007
出版者MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI
源URL[http://202.127.146.157/handle/2RYDP1HH/974]  
专题中国科学院武汉植物园
通讯作者Pan, Hong-Yu
作者单位1.Jilin Univ, Coll Plant Sci, Changchun 130062, Peoples R China
2.Jilin Agr Univ, Sch Resources & Environm, Changchun 130118, Peoples R China
3.Jilin Agr Univ, Inst Agr Modernizat, Changchun 130118, Peoples R China
4.Chinese Acad Sci, Wuhan Bot Garden, Wuhan 430074, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Hao,Sun, Guang-Zhi,Li, Xiang,et al. A New Geldanamycin Analogue from Streptomyces hygroscopicus[J]. MOLECULES,2010,15(3):1161-1167.
APA Zhang, Hao,Sun, Guang-Zhi,Li, Xiang,Pan, Hong-Yu,&Zhang, Yan-Sheng.(2010).A New Geldanamycin Analogue from Streptomyces hygroscopicus.MOLECULES,15(3),1161-1167.
MLA Zhang, Hao,et al."A New Geldanamycin Analogue from Streptomyces hygroscopicus".MOLECULES 15.3(2010):1161-1167.

入库方式： OAI收割

来源：武汉植物园

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