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Pharmacokinetics and tissue residues of difloxacin in crucian carp (Carassius auratus) after oral administration
文献类型：期刊论文
| 作者 | Ding, FK; Cao, JY; Ma, LB; Pan, QS; Fang, ZP; Lu, XC |
| 刊名 | AQUACULTURE
 |
| 出版日期 | 2006-06-15 |
| 卷号 | 256期号:1-4页码:121-128 |
| 关键词 | difloxacin pharmacokinctics residues dose regimen crucian carp withdrawal time |
| ISSN号 | 0044-8486 |
| DOI | 10.1016/j.aquaculture.2006.02.056 |
| 英文摘要 | The study was conducted to evaluate the pharmacokinetic disposition of difloxacin (DIF) with a single dose of 20 mg/kg body weight after oral administration in crucian carp (Carassius auratus, 250 +/- 30g) at water temperatures of 10 degrees C and 20 degrees C. DIF concentration in plasma and tissues was determined using high-performance liquid chromatography (HPLC). The plasma drug concentration-time data were fitted using a single-compartment model and a two-compartment model at 10 degrees C and 20 degrees C, respectively. The absorption rate constant (K-a) of DIF was found to be 0.85 and 1.27h(-1) at 10 degrees C and 20 degrees C, respectively, whereas the elimination half-life (t(1/2 beta)) of the drug was 95.36h at 10 degrees C and 48.93h at 20 degrees C. The area under the serum concentration-time curve (AUC) was 1361.79 mu gml(-1) h at 10 degrees C and 355.19 mu gml(-1) h at 20 degrees C. The distribution volume (V-d/F) of DIF was computed as 2.02 and 4.021kg(-1) at 10 degrees C and 20 degrees C, respectively. The total clearance of DIF (CLb) was estimated to be 0.015 and 0.0561h(-1)kg(-1) at 10 degrees C and 20 degrees C, respectively. The time-point of maximum plasma concentration of the drug (T-p) and the Jml at 10 degrees C and 2.21 h and 10.28 mu g/ml at 20 degrees C. After maximum plasma concentration (C-max) were calculated as 5.65 h and 9.49 mu g/ml repeated oral administration at a dosage of 20mg/kg body weight, DIF was detected in the muscle, liver, kidney, and skin for 15 days after the last administration. The results revealed that the depletion of DIF in the crucian carp becomes slower with a long half-life time, especially at lower water temperature. (c) 2006 Elsevier B.V. All fights reserved. |
| WOS研究方向 | Fisheries ; Marine & Freshwater Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000238394400014 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/1173]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Cao, JY |
| 作者单位 | 1.Huazhong Agr Univ, Coll Vet Med, Lab Physiol & Pharmacol, Wuhan 430070, Peoples R China 2.Huazhong Agr Univ, Coll Fisheries, Lab Aquaculture, Wuhan 430070, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Bot, Wuhan 430060, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ding, FK,Cao, JY,Ma, LB,et al. Pharmacokinetics and tissue residues of difloxacin in crucian carp (Carassius auratus) after oral administration[J]. AQUACULTURE,2006,256(1-4):121-128. |
| APA | Ding, FK,Cao, JY,Ma, LB,Pan, QS,Fang, ZP,&Lu, XC.(2006).Pharmacokinetics and tissue residues of difloxacin in crucian carp (Carassius auratus) after oral administration.AQUACULTURE,256(1-4),121-128. |
| MLA | Ding, FK,et al."Pharmacokinetics and tissue residues of difloxacin in crucian carp (Carassius auratus) after oral administration".AQUACULTURE 256.1-4(2006):121-128. |
入库方式： OAI收割
来源：武汉植物园
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