Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer
文献类型：期刊论文
| 作者 | Singh, Vishal1; Yeoh, Beng San2; Chassaing, Benoit3,4; Xiao, Xia5; Saha, Piu1; Olvera, Rodrigo Aguilera5; Lapek, John D., Jr.6; Zhang, Limin7,8,9; Wang, Wei-Bei7; Hao, Sijie10 |
| 刊名 | CELL
 |
| 出版日期 | 2018-10-18 |
| 卷号 | 175期号:3页码:679-+ |
| ISSN号 | 0092-8674 |
| DOI | 10.1016/j.cell.2018.09.004 |
| 英文摘要 | Dietary soluble fibers are fermented by gut bacteria into short-chain fatty acids (SCFA), which are considered broadly health-promoting. Accordingly, consumption of such fibers ameliorates metabolic syndrome. However, incorporating soluble fiber inulin, but not insoluble fiber, into a compositionally defined diet, induced icteric hepatocellular carcinoma (HCC). Such HCC was microbiota-dependent and observed in multiple strains of dysbiotic mice but not in germ-free nor antibiotics-treated mice. Furthermore, consumption of an inulin-enriched high-fat diet induced both dysbiosis and HCC in wild-type (WT) mice. Inulin-induced HCC progressed via early onset of cholestasis, hepatocyte death, followed by neutrophilic inflammation in liver. Pharmacologic inhibition of fermentation or depletion of fermenting bacteria markedly reduced intestinal SCFA and prevented HCC. Intervening with cholestyramine to prevent reabsorption of bile acids also conferred protection against such HCC. Thus, its benefits notwithstanding, enrichment of foods with fermentable fiber should be approached with great caution as it may increase risk of HCC. |
| 资助项目 | NIH[R01CA219144] ; NIH[R03DK094864] ; NIH[R01DK097865] ; NIH[DK061417] ; NIH[DK083890] ; Crohn's and Colitis Foundation of America (CCFA) ; CCFA Career Development Award ; FRS-FNRS ; Funds Baillet Latour ; ERC[2013 (336452-ENIGMO)] ; [WELBIO-CGR-2017-C2] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| 出版者 | CELL PRESS |
| WOS记录号 | WOS:000447780800012 |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/3913]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Vijay-Kumar, Matam |
| 作者单位 | 1.Univ Toledo, Dept Physiol & Pharmacol, UT Microbiome Consortium, Coll Med & Life Sci, Toledo, OH 43614 USA 2.Penn State Univ, Grad Program Immunol & Infect Dis, University Pk, PA 16802 USA 3.Georgia State Univ, Neurosci Inst, Atlanta, GA 30303 USA 4.Georgia State Univ, Inst Biomed Sci, Ctr Inflammat Immun & Infect, Atlanta, GA 30303 USA 5.Penn State Univ, Dept Nutr Sci, State Coll, PA 16802 USA 6.Univ Calif San Diego, Dept Pharmacol, San Diego, CA 92093 USA 7.Penn State Univ, Dept Vet & Biomed Sci, State Coll, PA 16802 USA 8.Chinese Acad Sci, Wuhan, Hubei, Peoples R China 9.State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan, Hubei, Peoples R China 10.Penn State Univ, Dept Biomed Chem, State Coll, PA 16802 USA |
| 推荐引用方式 GB/T 7714 | Singh, Vishal,Yeoh, Beng San,Chassaing, Benoit,et al. Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer[J]. CELL,2018,175(3):679-+. |
| APA | Singh, Vishal.,Yeoh, Beng San.,Chassaing, Benoit.,Xiao, Xia.,Saha, Piu.,...&Vijay-Kumar, Matam.(2018).Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer.CELL,175(3),679-+. |
| MLA | Singh, Vishal,et al."Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer".CELL 175.3(2018):679-+. |
入库方式： OAI收割
来源：武汉植物园
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