Anti-CD40-induced inflammatory E-cadherin plus dendritic cells enhance T cell responses and antitumour immunity in murine Lewis lung carcinoma
文献类型：期刊论文
| 作者 | Zhang, Yong1; Hu, Xiaoyan1; Hu, Yue1; Teng, Kai2; Zhang, Kai1; Zheng, Yamei3; Hong, Xiaohua1; Yu, Kunwu4; Wang, Yan5; Liu, Li1 |
| 刊名 | JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
 |
| 出版日期 | 2015-02-05 |
| 卷号 | 34页码:10 |
| 关键词 | E-cadherin Dendritic cell T cell Lung cancer Activity |
| ISSN号 | 1756-9966 |
| DOI | 10.1186/s13046-015-0126-9 |
| 英文摘要 | Background: Agonistic CD40 antibodies have been demonstrated to activate antigen-presenting cells (APCs) and enhance antitumour T cell responses, thereby providing a new therapeutic option in cancer immunotherapy. In agonistic CD40 antibody-mediated inflammatory responses, a novel subset of E-cadherin + dendritic cells (DCs) has been identified, and little is known about the role of these DCs in tumour immunity. This study investigated the effect of anti-CD40-mediated inflammatory E-cadherin + DCs in murine Lewis lung carcinoma (LLC). Methods: The phenotype and characteristics of anti-CD40-mediated inflammatory E-cadherin + DCs isolated from the anti-CD40 model were assessed in vitro. The antitumour activity of E-cadherin + DCs were evaluated in vivo by promoting the differentiation of effector CD4+ T cells, CEA-specific CD8+ T cells and CD103+ CD8+ T cells and assessing their resistance to tumour challenge, including variations in tumour volume and survival curves. Results: Here, we demonstrated that anti-CD40-mediated E-cadherin + inflammatory DCs accumulate in the lungs of Rag1 KO mice and were able to stimulate naive CD4+ T cells to induce Th1 and Th17 cell differentiation and polarisation and to inhibit regulatory T cell and Th2 responses. Importantly, with the adoptive transfer of E-cadherin + DCs into the Lewis lung cancer model, the inflammatory DCs increased the Th1 and Th17 cell responses and reduced the Treg cell and Th2 responses. Interestingly, following the injection of inflammatory E-cadherin + DCs, the CD103+ CD8+ T cell and CEA-specific CD8+ T cell responses increased and exhibited potent antitumour immunity. Conclusions: These findings indicate that anti-CD40-induced E-cadherin + DCs enhance T cell responses and antitumour activity in non-small cell lung cancer (NSCLC)-bearing mice and may be used to enhance the efficacy of DC-based peptide vaccines against NSCLC. |
| 资助项目 | National Natural Science Foundations of China[81171979] ; National Natural Science Foundations of China[81372260] ; Doctoral fund[20110142110005] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000350440200001 |
| 出版者 | BIOMED CENTRAL LTD |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/3994]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Liu, Li |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Ctr Canc, Wuhan 430023, Hubei, Peoples R China 2.Hainan Canc Hosp, Haikou, Hainan, Peoples R China 3.Cent Hosp Wuhan, Dept Oncol, Wuhan, Hunan, Peoples R China 4.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Inst Cardiol,Lab Cardiovasc Immunol, Wuhan 430023, Hubei, Peoples R China 5.Chinese Acad Sci, Anal & Testing Ctr, Inst Hydro Biol, Wuhan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yong,Hu, Xiaoyan,Hu, Yue,et al. Anti-CD40-induced inflammatory E-cadherin plus dendritic cells enhance T cell responses and antitumour immunity in murine Lewis lung carcinoma[J]. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,2015,34:10. |
| APA | Zhang, Yong.,Hu, Xiaoyan.,Hu, Yue.,Teng, Kai.,Zhang, Kai.,...&Liu, Li.(2015).Anti-CD40-induced inflammatory E-cadherin plus dendritic cells enhance T cell responses and antitumour immunity in murine Lewis lung carcinoma.JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,34,10. |
| MLA | Zhang, Yong,et al."Anti-CD40-induced inflammatory E-cadherin plus dendritic cells enhance T cell responses and antitumour immunity in murine Lewis lung carcinoma".JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 34(2015):10. |
入库方式： OAI收割
来源：武汉植物园
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