SNX8 modulates innate immune response to DNA virus by mediating trafficking and activation of MITA
文献类型：期刊论文
| 作者 | Wei, Jin1; Lian, Huan1; Guo, Wei1; Chen, Yun-Da1,2; Zhang, Xia-Nan1,2; Zang, Ru1; Zhong, Li1; Yang, Qing1; Hu, Ming-Ming1; Luo, Wei-Wei3 |
| 刊名 | PLOS PATHOGENS
 |
| 出版日期 | 2018-10-01 |
| 卷号 | 14期号:10页码:17 |
| ISSN号 | 1553-7366 |
| DOI | 10.1371/journal.ppat.1007336 |
| 英文摘要 | MITA (also called STING) is a central adaptor protein in innate immune response to cytosolic DNA. Cellular trafficking of MITA from the ER to perinuclear microsomes after DNA virus infection is critical for MITA activation and onset of innate antiviral response. Here we found that SNX8 is a component of DNA-triggered induction of downstream effector genes and innate immune response. Snx8(-/-) mice infected with the DNA virus HSV-1 exhibited lower serum cytokine levels and higher viral titers in the brains, resulting in higher lethality. Mechanistically, SNX8 recruited the class III phosphatylinositol 3-kinase VPS34 to MITA, which is required for trafficking of MITA from the ER to perinuclear microsomes. Our findings suggest that SNX8 is a critical component in innate immune response to cytosolic DNA and DNA virus. |
| 资助项目 | State Key R&D Program of China[2017YFA0505800] ; State Key R&D Program of China[2016YFA0502102] ; National Natural Science Foundation of China[31630045] ; National Natural Science Foundation of China[31521091] ; National Natural Science Foundation of China[31671465] |
| WOS研究方向 | Microbiology ; Parasitology ; Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000448978700024 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/4011]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Shu, Hong-Bing; Li, Shu |
| 作者单位 | 1.Wuhan Univ, Med Res Inst, Sch Med, Wuhan, Hubei, Peoples R China 2.Wuhan Univ, Coll Life Sci, Sch Med, Wuhan, Hubei, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Virol, Wuhan, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Jin,Lian, Huan,Guo, Wei,et al. SNX8 modulates innate immune response to DNA virus by mediating trafficking and activation of MITA[J]. PLOS PATHOGENS,2018,14(10):17. |
| APA | Wei, Jin.,Lian, Huan.,Guo, Wei.,Chen, Yun-Da.,Zhang, Xia-Nan.,...&Li, Shu.(2018).SNX8 modulates innate immune response to DNA virus by mediating trafficking and activation of MITA.PLOS PATHOGENS,14(10),17. |
| MLA | Wei, Jin,et al."SNX8 modulates innate immune response to DNA virus by mediating trafficking and activation of MITA".PLOS PATHOGENS 14.10(2018):17. |
入库方式： OAI收割
来源：武汉植物园
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