HORMONAL REPLACEMENT THERAPY IN FISH - HUMAN GROWTH-HORMONE GENE-FUNCTION IN HYPOPHYSECTOMIZED CARP
文献类型：期刊论文
| 作者 | CUI, ZB; ZHU, ZY |
| 刊名 | FISH PHYSIOLOGY AND BIOCHEMISTRY
 |
| 出版日期 | 1993-08-01 |
| 卷号 | 12期号:2页码:161-169 |
| 关键词 | COMMON CARP CRUCIAN CARP GROWTH HORMONE GROWTH HORMONE GENE TRANSGENIC FISH HORMONAL REPLACEMENT HYPOPHYSECTOMY |
| ISSN号 | 0920-1742 |
| 英文摘要 | Transgenic common carp, Cyprinus carpio, produced by the microinjection of fertilized eggs with a linearized chimeric plasmid pMThGH, a human growth hormone (hGH) gene with a mouse metallothionein-I (MT) gene promoter in pBR322, were used to produce F1 and F2 transgenics. Following hypophysectomy of the transgenic F2 common carp, non-transgenic common carp and non-transgenic crucian carp, growth was monitored for up to 110 days. In addition, recombinant hGH was injected subcutaenously into a group of the non-transgenic crucian carp. Growth rate analyses indicated that (1) hypophysectomy of non-transgenic common carp and crucian carp results in the cessation of growth, (2) hGH administration can stimulate the growth of hypophysectomized crucian carp and (3) hypophysectomized hGH-transgenic common carp continue to grow in the absence of their own growth hormone, suggesting that the hGH-transgene is being expressed in tissues other than the pituitary. |
| WOS研究方向 | Biochemistry & Molecular Biology ; Fisheries ; Physiology |
| 语种 | 英语 |
| WOS记录号 | WOS:A1993LZ11300009 |
| 出版者 | KUGLER PUBLICATIONS BV |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/4014]  |
| 专题 | 中国科学院武汉植物园 |
| 作者单位 | 1.UNIV ABERDEEN,DEPT MOLEC & CELL BIOL,ABERDEEN AB9 2TN,SCOTLAND 2.CHINESE ACAD SCI,INST HYDROBIOL,WUHAN,HUBEI 430072,PEOPLES R CHINA 3.UNIV ABERDEEN,DEPT ZOOL,ABERDEEN AB9 2TN,SCOTLAND |
| 推荐引用方式 GB/T 7714 | CUI, ZB,ZHU, ZY. HORMONAL REPLACEMENT THERAPY IN FISH - HUMAN GROWTH-HORMONE GENE-FUNCTION IN HYPOPHYSECTOMIZED CARP[J]. FISH PHYSIOLOGY AND BIOCHEMISTRY,1993,12(2):161-169. |
| APA | CUI, ZB,&ZHU, ZY.(1993).HORMONAL REPLACEMENT THERAPY IN FISH - HUMAN GROWTH-HORMONE GENE-FUNCTION IN HYPOPHYSECTOMIZED CARP.FISH PHYSIOLOGY AND BIOCHEMISTRY,12(2),161-169. |
| MLA | CUI, ZB,et al."HORMONAL REPLACEMENT THERAPY IN FISH - HUMAN GROWTH-HORMONE GENE-FUNCTION IN HYPOPHYSECTOMIZED CARP".FISH PHYSIOLOGY AND BIOCHEMISTRY 12.2(1993):161-169. |
入库方式： OAI收割
来源：武汉植物园
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