Human immunodeficiency virus-1 genotypic drug resistance among volunteer blood donors in Yunnan, China
文献类型：期刊论文
| 作者 | Tu, Yuan-Quan; Wang, Min-Jie; Yao, Jun; Zhu, Xiang-Ming; Pan, Pin-Liang; Xing, Wen-Ge; Zhang, Gao-Hong; Yang, Rong-Ge; Zheng, Yong-Tang; Jiang, Yan |
| 刊名 | TRANSFUSION
 |
| 出版日期 | 2009-09-01 |
| 卷号 | 49期号:9页码:1865-1873 |
| ISSN号 | 0041-1132 |
| DOI | 10.1111/j.1537-2995.2009.02219.x |
| 英文摘要 | BACKGROUND: Drug resistance profiles of human immunodeficiency virus-1 (HIV-1) in treatment-naive infections have been reported in developed countries. However, little is known in developing countries, including China, especially in treatment-naive volunteer blood donors. STUDY DESIGN AND METHODS: Fifty-two HIV-1 positive samples of blood donors were collected from 2005 to 2006 in Yunnan, China. Recent and long-term infections were distinguished by the HIV-1 subtypes B, E, and D immunoglobulin G-capture enzyme immunoassay assay. The nucleotide sequences of pol genes were amplified and sequenced. Phylogenetic tree and drug resistance analyses were performed. RESULTS: Of 49 samples successfully analyzed, circulating strains were circulating recombinant form (CRF) 08_BC (51.0%), CRF07_BC (24.5%), CRF01_AE (20.4%), and B (4.1%). No protease inhibitors (PI) major drug resistance mutation (DRM) was detected. Six samples (12.2%) displayed seven minor PI DRMs. Nine samples (18.4%) displayed 10 nucleoside reverse transcriptase inhibitor DRMs, and DRMs to nonnucleoside reverse transcriptase inhibitors were present in one sample (2.0%). There was only one sample of the 49 (2.0%) in which the DRMs were of sufficient magnitude to result in a clinical change to drug susceptibility, but even in this sample, the clinical effect of these DRMs was predicted to be low. Significant differences were not observed between the long-term and recent infected population. Differences in DRMs were not observed between peripheral blood mononuclear cells and plasma within an individual. CONCLUSIONS: CRF_BC was the dominant subtype circulating in HIV-1-infected donors in Yunnan. Prevalence of genotypic drug resistances among donors in Yunnan was low in this study. Surveillance on HIV-1 infections among blood donors should be continued in China. |
| 资助项目 | National 973 project of China[2006CB504208] ; National 973 project of China[2006CB504302] ; Natural Science Foundation of China[30671960] ; Natural Science Foundation of China[U0832601] ; Key Scientific and Technological projects of China[2004BA719A14] |
| WOS研究方向 | Hematology |
| 语种 | 英语 |
| WOS记录号 | WOS:000269391800014 |
| 出版者 | WILEY-BLACKWELL PUBLISHING, INC |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/4080]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Zheng, Yong-Tang |
| 作者单位 | 1.Chinese Acad Sci, Lab Mol Immunopharmacol, Key Lab Anim Models & Human Dis Mech, Kunming Inst Zool, Kunming, Peoples R China 2.Yunnan Kunming Blood Ctr, Kunming, Peoples R China 3.Chinese Acad Sci, Natl AIDS Reference Lab, Natl Ctr AIDS STD Control & Prevent, Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 5.Chinese Acad Sci, Wuhan Inst Virol, Wuhan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tu, Yuan-Quan,Wang, Min-Jie,Yao, Jun,et al. Human immunodeficiency virus-1 genotypic drug resistance among volunteer blood donors in Yunnan, China[J]. TRANSFUSION,2009,49(9):1865-1873. |
| APA | Tu, Yuan-Quan.,Wang, Min-Jie.,Yao, Jun.,Zhu, Xiang-Ming.,Pan, Pin-Liang.,...&Jiang, Yan.(2009).Human immunodeficiency virus-1 genotypic drug resistance among volunteer blood donors in Yunnan, China.TRANSFUSION,49(9),1865-1873. |
| MLA | Tu, Yuan-Quan,et al."Human immunodeficiency virus-1 genotypic drug resistance among volunteer blood donors in Yunnan, China".TRANSFUSION 49.9(2009):1865-1873. |
入库方式： OAI收割
来源：武汉植物园
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