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Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice

文献类型：期刊论文

作者Borkowski, Kamil5; Harvatine, Kevin J.11; Xiao, Xia5; Yeoh, Beng San5; Zhang, Limin7,8,9,10; Chassaing, Benoit6; Singh, Nagendra1; Singh, Vishal5; Shearer, Gregory C.5; Ntambi, James M.2
刊名CELL METABOLISM
出版日期2015-12-01
卷号22期号:6页码:983-996
ISSN号1550-4131
DOI10.1016/j.cmet.2015.09.028
英文摘要The gut microbiota plays a key role in host metabolism. Toll-like receptor 5 (TLR5), a flagellin receptor, is required for gut microbiota homeostasis. Accordingly, TLR5-deficient (T5KO) mice are prone to develop microbiota-dependent metabolic syndrome. Here we observed that T5KO mice display elevated neutral lipids with a compositional increase of oleate [C18:1 (n9)] relative to wild-type littermates. Increased oleate contribution to hepatic lipids and liver SCD1 expression were both microbiota dependent. Analysis of short-chain fatty acids (SCFAs) and C-13-acetate label incorporation revealed elevated SCFA in ceca and hepatic portal blood and increased liver de novo lipogenesis in T5KO mice. Dietary SCFAs further aggravated metabolic syndrome in T5KO mice. Deletion of hepatic SCD1 not only prevented hepatic neutral lipid oleate enrichment but also ameliorated metabolic syndrome in T5KO mice. Collectively, these results underscore the key role of the gut microbiota-liver axis in the pathogenesis of metabolic diseases.
资助项目NIH[DK083275] ; NIH[DK094864] ; NIH[DK097865-01A1] ; NIH[T32AI07445] ; NIH[ES022186] ; NIH[R01HL11264] ; NIH[R01HL020176] ; Crohn's and Colitis Foundation of America (CCFA) ; Pennsylvania Department of Health using Tobacco CURE Funds ; [DK061417] ; [DK083890]
WOS研究方向Cell Biology ; Endocrinology & Metabolism
语种英语
出版者CELL PRESS
WOS记录号WOS:000365993100007
源URL[http://202.127.146.157/handle/2RYDP1HH/4154]  
专题中国科学院武汉植物园
通讯作者Vijay-Kumar, Matam
作者单位1.Georgia Regents Univ, Biochem & Mol Biol, Augusta, GA 30912 USA
2.Univ Wisconsin, Dept Biochem & Nutr Sci, Madison, WI 53706 USA
3.Univ Toledo, Dept Physiol & Pharmacol, Coll Med & Life Sci, Toledo, OH 43614 USA
4.Penn State Univ, Dept Med, Med Ctr, Hershey, PA 17033 USA
5.Penn State Univ, Dept Nutr Sci, University Pk, PA 16802 USA
6.Georgia State Univ, Inst Biomed Sci, Ctr Inflammat Immun & Infect, Atlanta, GA 30303 USA
7.Penn State Univ, Dept Vet & Biomed Sci, Ctr Mol Toxicol & Carcinogenesis, University Pk, PA 16802 USA
8.Chinese Acad Sci, Wuhan, Peoples R China
9.State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan, Peoples R China
10.Natl Ctr Magnet Resonance, Wuhan, Peoples R China
推荐引用方式
GB/T 7714		 Borkowski, Kamil,Harvatine, Kevin J.,Xiao, Xia,et al. Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice[J]. CELL METABOLISM,2015,22(6):983-996.
APA Borkowski, Kamil.,Harvatine, Kevin J..,Xiao, Xia.,Yeoh, Beng San.,Zhang, Limin.,...&Kumar, Manish.(2015).Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice.CELL METABOLISM,22(6),983-996.
MLA Borkowski, Kamil,et al."Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice".CELL METABOLISM 22.6(2015):983-996.

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来源：武汉植物园

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