Detection of Smoke-Induced Pulmonary Lesions by Hyperpolarized Xe-129 Diffusion Kurtosis Imaging in Rat Models
文献类型：期刊论文
| 作者 | Ye, Chaohui1,2; Ruan, Weiwei1,2; Zhong, Jianping1; Guan, Yu3; Xia, Yi3; Zhao, Xiuchao1; Han, Yeqing1; Sun, Xianping1,2; Liu, Shiyuan3; Zhou, Xin1,2 |
| 刊名 | MAGNETIC RESONANCE IN MEDICINE
 |
| 出版日期 | 2017-11-01 |
| 卷号 | 78期号:5页码:1891-1899 |
| 关键词 | hyperpolarized xenon DKI smoke Dapp Kapp pulmonary lesions |
| ISSN号 | 0740-3194 |
| DOI | 10.1002/mrm.26566 |
| 英文摘要 | Purpose: To demonstrate that hyperpolarized (HP) xenon diffusion kurtosis imaging (DKI) is able to detect smoke-induced pulmonary lesions in rat models. Methods: Multi-b DKI with hyperpolarized xenon was used for the first time in five smoke-exposed rats and five healthy rats. Additionally, DKI with b values of up to 80 s/cm(2) were used in two healthy rats to probe the critical b value (a limit beyond which the DKI cannot describe the non-Gaussian diffusion). Results: The mean apparent diffusion coefficient (Dapp) and diffusion kurtosis (K-app) extracted by the DKI model revealed significant changes in the smoke-exposed rats compared with those in the control group (P = 0.027 and 0.039, respectively), exhibiting strong correlations with mean linear intercept (L-m) from the histology. Although the maximum b value was increased to 80 s/cm(2), the DKI could still describe the nonGaussian diffusion (R-2 > 0.97). Conclusion: DKI with hyperpolarized xenon exhibited sensitivity in the detection of pulmonary lesions induced by smoke, including moderate emphysema and small airway diseases. The critical b value was rarely exceeded in DKI of the lungs due to the limited gradient strength of the MRI scanner used in our study. (C) 2016 International Society for Magnetic Resonance in Medicine. |
| 资助项目 | National Natural Science Foundation of China[81227902] ; National Natural Science Foundation of China[81625011] ; National Program for Special Support of Eminent Professionals (National Program for Support of Top-notch Young Professionals) |
| WOS研究方向 | Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000416390700024 |
| 出版者 | WILEY |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/4344]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Zhou, Xin |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Phys & Math, Natl Ctr Magnet Resonance Wuhan,Key Lab Magnet Re, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan, Hubei, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Second Mil Med Univ, Changzheng Hosp, Dept Radiol, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ye, Chaohui,Ruan, Weiwei,Zhong, Jianping,et al. Detection of Smoke-Induced Pulmonary Lesions by Hyperpolarized Xe-129 Diffusion Kurtosis Imaging in Rat Models[J]. MAGNETIC RESONANCE IN MEDICINE,2017,78(5):1891-1899. |
| APA | Ye, Chaohui.,Ruan, Weiwei.,Zhong, Jianping.,Guan, Yu.,Xia, Yi.,...&Zhou, Xin.(2017).Detection of Smoke-Induced Pulmonary Lesions by Hyperpolarized Xe-129 Diffusion Kurtosis Imaging in Rat Models.MAGNETIC RESONANCE IN MEDICINE,78(5),1891-1899. |
| MLA | Ye, Chaohui,et al."Detection of Smoke-Induced Pulmonary Lesions by Hyperpolarized Xe-129 Diffusion Kurtosis Imaging in Rat Models".MAGNETIC RESONANCE IN MEDICINE 78.5(2017):1891-1899. |
入库方式： OAI收割
来源：武汉植物园
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