A picorna-like virus suppresses the N-end rule pathway to inhibit apoptosis
文献类型：期刊论文
| 作者 | Xu, Jiuyue2; Zhou, Xi1,2; Wang, Zhaowei1,2; Xia, Xiaoling1,2,3,4; Yang, Xueli1; Zhang, Xueyi1,2; Liu, Yongxiang1,2; Wu, Di1,2; Fang, Yuan1,2; Liu, Yujie1,2 |
| 刊名 | ELIFE
 |
| 出版日期 | 2017-12-12 |
| 卷号 | 6页码:22 |
| ISSN号 | 2050-084X |
| DOI | 10.7554/eLife.30590.001 |
| 英文摘要 | The N-end rule pathway is an evolutionarily conserved proteolytic system that degrades proteins containing N-terminal degradation signals called N-degrons, and has emerged as a key regulator of various processes. Viruses manipulate diverse host pathways to facilitate viral replication and evade antiviral defenses. However, it remains unclear if viral infection has any impact on the N-end rule pathway. Here, using a picorna-like virus as a model, we found that viral infection promoted the accumulation of caspase-cleaved Drosophila inhibitor of apoptosis 1 (DIAP1) by inducing the degradation of N-terminal amidohydrolase 1 (NTAN1), a key N-end rule component that identifies N-degron to initiate the process. The virus-induced NTAN1 degradation is independent of polyubiquitylation but dependent on proteasome. Furthermore, the virus-induced N-end rule pathway suppression inhibits apoptosis and benefits viral replication. Thus, our findings demonstrate that a virus can suppress the N-end rule pathway, and uncover a new mechanism for virus to evade apoptosis. |
| 资助项目 | National Natural Science Foundation of China[31522004] ; National Natural Science Foundation of China[31600126] ; Academy of Medical Sciences[31761130075] ; National Basic Research Program of China[2014CB542603] ; Chinese Academy of Sciences[XDPB0301] ; Natural Science Foundation of Hubei Province[2016CFA045] ; National High-Tech R&D Program of China[2015AA020939] |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
| 语种 | 英语 |
| 出版者 | ELIFE SCIENCES PUBLICATIONS LTD |
| WOS记录号 | WOS:000418401000001 |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/4432]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Zhou, Xi |
| 作者单位 | 1.Wuhan Univ, Coll Life Sci, State Key Lab Virol, Wuhan, Hubei, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Hubei, Peoples R China 3.South China Normal Univ, Inst Insect Sci & Technol, Guangzhou Key Lab Insect Dev Regulat & Applicat R, Guangzhou, Guangdong, Peoples R China 4.South China Normal Univ, Sch Life Sci, Guangzhou, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Jiuyue,Zhou, Xi,Wang, Zhaowei,et al. A picorna-like virus suppresses the N-end rule pathway to inhibit apoptosis[J]. ELIFE,2017,6:22. |
| APA | Xu, Jiuyue.,Zhou, Xi.,Wang, Zhaowei.,Xia, Xiaoling.,Yang, Xueli.,...&Qiu, Yang.(2017).A picorna-like virus suppresses the N-end rule pathway to inhibit apoptosis.ELIFE,6,22. |
| MLA | Xu, Jiuyue,et al."A picorna-like virus suppresses the N-end rule pathway to inhibit apoptosis".ELIFE 6(2017):22. |
入库方式： OAI收割
来源：武汉植物园
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