Serologic and viral genome prevalence of HSV, EBV, and HCMV among healthy adults in Wuhan, China
文献类型：期刊论文
| 作者 | Ruan, Qiang5; Zhao, Fei1; Hu, Fei3; Luo, Min-Hua1,2,4; Qiu, Yong3; Cui, Jie1; Wang, Wei; Wen, Le1,2; Cheng, Shuang1; Jiang, Xuan1,4 |
| 刊名 | JOURNAL OF MEDICAL VIROLOGY
 |
| 出版日期 | 2018-03-01 |
| 卷号 | 90期号:3页码:571-581 |
| 关键词 | central China Epstein-Barr virus (EBV) healthy adult herpes simplex virus (HSV) human cytomegalovirus (HCMV) immunoglobulin G (IgG) immunoglobulin M (IgM) prevalence viral genomic DNA |
| ISSN号 | 0146-6615 |
| DOI | 10.1002/jmv.24989 |
| 英文摘要 | The worldwide infection rate of herpesvirus is high, but the detailed prevalence in China, especially the central area, remains unclear. In the present study, the prevalence of herpes simplex virus (HSV), Epstein-Barr virus (EBV), and human cytomegalovirus (HCMV) was investigated in 303 healthy adults in Wuhan, a representative city in Central China. Viral-specific IgG and IgM titers were examined in the serum by chemiluminescent immunoassay, and the existence of viral genomic DNA in blood cells was determined by nested PCR. The overall IgG seroprevalences were 81.5%, 95.4%, and 93.7% for HSV, EBV, and HCMV, while the corresponding IgM seroprevalences were only 6.3%, 2.3%, and 0. The viral genomic DNA of HSV, EBV, and HCMV was identified in the blood samples of 5.9%, 14.2%, and 22.8% of the tested donors, respectively. Significantly, less HSV IgM-positive samples were found in the population over 20 years old than below 20 group; female displayed higher chances for HSV IgG and genome positivity; and occupations such as waiters and medical staffs were shown to be with higher risk for HCMV genome positivity. This study provided useful reference data for the HSV, EBV, and HCMV prevalence in central China, and suggested the potential importance of detecting viral genome to complement serum test data. |
| 资助项目 | National Natural Science Foundation of China[81601770] ; National Natural Science Foundation of China[81620108021] |
| WOS研究方向 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000419510600025 |
| 出版者 | WILEY |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/4491]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Hu, Fei; Luo, Min-Hua |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Virol, CEBSIT, Wuhan Inst Virol, Wuhan, Hubei, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Wuhan Brain Hosp, Minist Transportat, Huiji Rd 5, Wuhan 430010, Hubei, Peoples R China 4.Guangzhou Women & Children Med Ctr, Guangzhou Inst Pediat, Guangzhou, Guangdong, Peoples R China 5.China Med Univ, Virus Lab, Affiliated Shengjing Hosp, Shenyang, Peoples R China 6.South Cent Univ, Xiangya Hosp 3, Changsha, Hunan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ruan, Qiang,Zhao, Fei,Hu, Fei,et al. Serologic and viral genome prevalence of HSV, EBV, and HCMV among healthy adults in Wuhan, China[J]. JOURNAL OF MEDICAL VIROLOGY,2018,90(3):571-581. |
| APA | Ruan, Qiang.,Zhao, Fei.,Hu, Fei.,Luo, Min-Hua.,Qiu, Yong.,...&Fang, Wei.(2018).Serologic and viral genome prevalence of HSV, EBV, and HCMV among healthy adults in Wuhan, China.JOURNAL OF MEDICAL VIROLOGY,90(3),571-581. |
| MLA | Ruan, Qiang,et al."Serologic and viral genome prevalence of HSV, EBV, and HCMV among healthy adults in Wuhan, China".JOURNAL OF MEDICAL VIROLOGY 90.3(2018):571-581. |
入库方式： OAI收割
来源：武汉植物园
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