Engineering of Fc Fragments with Optimized Physicochemical Properties Implying Improvement of Clinical Potentials for Fc-Based Therapeutics
文献类型：期刊论文
| 作者 | Yang, Chunpeng1,2; Gao, Xinyu1,2; Gong, Rui1 |
| 刊名 | FRONTIERS IN IMMUNOLOGY
 |
| 出版日期 | 2018-01-08 |
| 卷号 | 8页码:14 |
| 关键词 | monoclonal antibody Fc-fusion protein Fc-based therapeutics optimization physicochemical property stability aggregation |
| ISSN号 | 1664-3224 |
| DOI | 10.3389/fimmu.2017.01860 |
| 英文摘要 | Therapeutic monoclonal antibodies and Fc-fusion proteins are successfully used in treatment of various diseases mainly including cancer, immune disease, and viral infection, which belong to the Fc-based therapeutics. In recent years, engineered Fc-derived antibody domains have also shown potential for Fc-based therapeutics. To increase the druggability of Fc-based therapeutic candidates, many efforts have been made in optimizing physicochemical properties and functions mediated by Fc fragment. The desired result is that we can simultaneously obtain Fc variants with increased physicochemical properties in vitro and capacity of mediating appropriate functions in vivo. However, changes of physicochemical properties of Fc may result in alternation of Fc-mediated functions and vice versa, which leads to undesired outcomes for further development of Fc-based therapeutics. Therefore, whether modified Fc fragments are suitable for achievement of expected clinical results or not needs to be seriously considered. Now, this question comes to be noticed and should be figured out to make better translation from the results of laboratory into clinical applications. In this review, we summarize different strategies on engineering physicochemical properties of Fc, and preliminarily elucidate the relationships between modified Fc in vitro and the subsequent therapeutic influence in vivo. |
| 资助项目 | Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12020346] ; Key Program of Chinese Academy of Sciences[ZDRW-ZS-2016-4] ; National Key Research and Development Program of China[2016YFC1202902] ; One-Three-Five Strategic Programs of Wuhan Institute of Virology, Chinese Academy of Sciences[Y605221SA1] ; Wuhan Key Laboratory on Emerging Infectious Diseases and Biosafety |
| WOS研究方向 | Immunology |
| 语种 | 英语 |
| WOS记录号 | WOS:000419445800001 |
| 出版者 | FRONTIERS MEDIA SA |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/4499]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Gong, Rui |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Chunpeng,Gao, Xinyu,Gong, Rui. Engineering of Fc Fragments with Optimized Physicochemical Properties Implying Improvement of Clinical Potentials for Fc-Based Therapeutics[J]. FRONTIERS IN IMMUNOLOGY,2018,8:14. |
| APA | Yang, Chunpeng,Gao, Xinyu,&Gong, Rui.(2018).Engineering of Fc Fragments with Optimized Physicochemical Properties Implying Improvement of Clinical Potentials for Fc-Based Therapeutics.FRONTIERS IN IMMUNOLOGY,8,14. |
| MLA | Yang, Chunpeng,et al."Engineering of Fc Fragments with Optimized Physicochemical Properties Implying Improvement of Clinical Potentials for Fc-Based Therapeutics".FRONTIERS IN IMMUNOLOGY 8(2018):14. |
入库方式： OAI收割
来源：武汉植物园
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