Novel Sodium Channel Inhibitor From Leeches
文献类型：期刊论文
| 作者 | Lu, Qiumin1,4; Meng, Ping1; Li, Dongsheng1; Luo, Xiaodong3; Sun, Zhaohui5; Rong, Mingqiang1; Wang, Gan1; Long, Chengbo1; Liu, Weihui1; Xu, Cheng1 |
| 刊名 | FRONTIERS IN PHARMACOLOGY
 |
| 出版日期 | 2018-03-06 |
| 卷号 | 9页码:9 |
| ISSN号 | 1663-9812 |
| 关键词 | leech therapy blood-sucking sodium channel pain analgesia |
| DOI | 10.3389/fphar.2018.00186 |
| 英文摘要 | Considering blood-sucking habits of leeches from surviving strategy of view, it can be hypothesized that leech saliva has analgesia or anesthesia functions for leeches to stay undetected by the host. However, no specific substance with analgesic function has been reported from leech saliva although clinical applications strongly indicated that leech therapy produces a strong and long lasting pain-reducing effect. Herein, a novel family of small peptides (HSTXs) including 11 members which show low similarity with known peptides was identified from salivary glands of the leech Haemadipsa sylvestris. A typical HSTX is composed of 22-25 amino acid residues including four half-cysteines, forming two intra-molecular disulfide bridges, and an amidated C-terminus. HSTX-I exerts significant analgesic function by specifically inhibiting voltage-gated sodium (Nay) channels (Nav1.8 and Nav1.9) which contribute to action potential electrogenesis in neurons and potential targets to develop analgesics. This study reveals that sodium channel inhibitors are analgesic substances in the leech. HSTXs are excellent candidates or templates for development of analgesics. |
| 资助项目 | National Natural Science Foundation of China[31630075] ; National Natural Science Foundation of China[31600721] ; National Natural Science Foundation of China[21761142002] ; Chinese Academy of Sciences[SAJC201606] ; Chinese Academy of Sciences[2015CASEABRI002] ; Chinese Academy of Sciences[ZSTH-017] ; Yunnan Province[2016FA006] ; Yunnan Province[2015BC005] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | FRONTIERS MEDIA SA |
| WOS记录号 | WOS:000426696000001 |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/4677]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Luo, Xiaodong; Sun, Zhaohui; Lai, Ren |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Key Lab Bioact Peptides Yunnan Prov, Kunming, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 4.Chinese Acad Sci, Sino African Joint Res Ctr, Wuhan, Hubei, Peoples R China 5.Guangzhou Gen Hosp Guangzhou Mil Command PLA, Dept Clin Lab, Guangzhou, Guangdong, Peoples R China 6.Nanjing Agr Univ, Life Sci Coll, Nanjing, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Qiumin,Meng, Ping,Li, Dongsheng,et al. Novel Sodium Channel Inhibitor From Leeches[J]. FRONTIERS IN PHARMACOLOGY,2018,9:9. |
| APA | Lu, Qiumin.,Meng, Ping.,Li, Dongsheng.,Luo, Xiaodong.,Sun, Zhaohui.,...&Li, Qiong.(2018).Novel Sodium Channel Inhibitor From Leeches.FRONTIERS IN PHARMACOLOGY,9,9. |
| MLA | Lu, Qiumin,et al."Novel Sodium Channel Inhibitor From Leeches".FRONTIERS IN PHARMACOLOGY 9(2018):9. |
入库方式： OAI收割
来源：武汉植物园
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