Genetic Analysis of Reemerging GII.P16-GII.2 Noroviruses in 2016-2017 in China
文献类型：期刊论文
| 作者 | Tan, Ming1; Ao, Yuanyun4; Duan, Zhaojun4; Cong, Xin4; Jin, Miao4; Sun, Xiaoman4; Wei, Xiaoman5; Wang, Jinjin6; Zhang, Qing4; Song, Jiao2 |
| 刊名 | JOURNAL OF INFECTIOUS DISEASES
 |
| 出版日期 | 2018-07-01 |
| 卷号 | 218期号:1页码:133-143 |
| 关键词 | norovirus reemerging GII.P16-GII.2 phylogenetic analysis histo-blood group antigen crystal structure |
| ISSN号 | 0022-1899 |
| DOI | 10.1093/infdis/jiy182 |
| 英文摘要 | Background. During 2016-2017, the previously rare GII.P16-GII.2 norovirus suddenly emerged as the predominant genotype causing gastroenteritis outbreaks in China and other countries. Its origin, phylodynamics, and mechanism behind the predominance remain unclear. Methods. Bayesian phylogenetic analyses were performed on 180 full capsid and 150 polymerase sequences of 2016-2017 GII.P16-GII.2 noroviruses in China, and those for all publicly available GII.P16andGII.2 sequences. Saliva-based histo-blood group antigen (HBGA) binding assays and crystal structural analysis were conducted by using the P proteins of 2016-2017 GII.P16-GII.2 noroviruses. Results. The reemerging GII.P16-GII.2 norovirus showed a rapid genetic diversification after its emergence in 2012-2013. The antigenicity and HBGA binding profile of the early 2016-2017 and pre-2016 GII.2 noroviruses were similar. A further variant with a single Val256Ile mutation and the conventionally orientated Asp382 in the VP1 protein showed an expanded HBGA-binding spectrum. Mutations on the surface of polymerase that could alter its function were seen, which may help to accelerate the VP1 gene evolution to 5.5 x 10(-3) substitutions per site per year. This virus can be traced back to Pearl River Delta, China. Conclusions. Our findings provide new insights into GII.2 norovirus epidemics and highlight the necessity of enhanced global surveillance for potential epidemics of rare-genotype noroviruses. |
| 资助项目 | Special National Project on Research and Development of Key Biosafety Technologies[2016YFC1201900] ; National Natural Science Foundation of China[31500139] ; National Natural Science Foundation of China[81702007] |
| WOS研究方向 | Immunology ; Infectious Diseases ; Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000434930900016 |
| 出版者 | OXFORD UNIV PRESS INC |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/5297]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Duan, Zhaojun |
| 作者单位 | 1.Cincinnati Childrens Hosp Med Ctr, Div Infect Dis, Cincinnati, OH 45229 USA 2.Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou, Gansu, Peoples R China 3.Chinese Acad Sci, Inst Microbiol, Beijing, Peoples R China 4.Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, 155 Changbai Rd, Beijing 102206, Peoples R China 5.Chinese Acad Sci, Wuhan Inst Virol, Ctr Emerging Infect Dis, Key Lab Special Pathogens & Biosafety, Wuhan, Hubei, Peoples R China 6.Shanghai Ocean Univ, Coll Food Sci & Technol, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tan, Ming,Ao, Yuanyun,Duan, Zhaojun,et al. Genetic Analysis of Reemerging GII.P16-GII.2 Noroviruses in 2016-2017 in China[J]. JOURNAL OF INFECTIOUS DISEASES,2018,218(1):133-143. |
| APA | Tan, Ming.,Ao, Yuanyun.,Duan, Zhaojun.,Cong, Xin.,Jin, Miao.,...&Qi, Jianxun.(2018).Genetic Analysis of Reemerging GII.P16-GII.2 Noroviruses in 2016-2017 in China.JOURNAL OF INFECTIOUS DISEASES,218(1),133-143. |
| MLA | Tan, Ming,et al."Genetic Analysis of Reemerging GII.P16-GII.2 Noroviruses in 2016-2017 in China".JOURNAL OF INFECTIOUS DISEASES 218.1(2018):133-143. |
入库方式： OAI收割
来源：武汉植物园
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