Dynamic changes in the immunological characteristics of T lymphocytes in surviving patients with severe fever with thrombocytopenia syndrome (SFTS)
文献类型：期刊论文
| 作者 | Liu, Jia3; Li, Ming-Yue3; Zhang, Yan-Fang4; Xiong, Yan3; Xiong, Shu-E3; Zou, Cong-Cong3; Xiong, Lei-Qun3; Liang, Bo-Yun3; Lu, Meng-Ji2; Peng, Cheng3 |
| 刊名 | INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
 |
| 出版日期 | 2018-05-01 |
| 卷号 | 70页码:72-80 |
| 关键词 | Severe fever with thrombocytopenia syndrome T lymphocytes Apoptosis T cell proliferation T cell activation PD-1 T cell functionality |
| ISSN号 | 1201-9712 |
| DOI | 10.1016/j.ijid.2018.03.010 |
| 英文摘要 | Objective: Severe fever with thrombocytopenia syndrome (SETS) is an emerging infectious disease with high mortality. T cell deficiency has recently been described, but the changes in T cell functionality during acute SETS virus (SETSV) infection and the mechanisms leading to T lymphocyte death remain largely unknown. This study was conducted to evaluate T cell functionality and the expression of apoptotic/ proliferation and activation/inhibition markers during acute SETSV infection. Methods: Twenty-eight surviving SETS patients were sequentially sampled during their entire hospital stay. SETSV RNA copies were investigated using real-time RT-PCR. The expression levels of apoptotic markers (annexin V and CD95) and proliferation and activation markers (Ki-67, HEA-DR, and CD25) and the expression levels of programmed cell death-1 (PD-1), interferon gamma (IFN-gamma), and granzyme B in T cells were evaluated by flow cytometry for the SETS patients. Results: In parallel with T cell depletion, higher annexin V and CD95 expression was observed in SETS patients. Additionally, the expression levels of Ki-67, HLA-DR, CD25, and PD-1 and the levels of IFN-gamma and granzyme B in T lymphocytes were markedly increased in the SFTS patients. Conclusions: T cell proliferation, activation, and functional enhancement were apparent despite the observation of T cell apoptosis, suggesting that these processes are involved in the complex protective response to SFTSV infection. (C) 2018 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. |
| 资助项目 | National Natural Science Foundation of China[81271884] ; Wuhan Union Hospital Faculty Research Funding from Huazhong University of Science and Technology[000003385] |
| WOS研究方向 | Infectious Diseases |
| 语种 | 英语 |
| WOS记录号 | WOS:000432658100014 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/5353]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Peng, Cheng; Zheng, Xin |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pediat, Wuhan, Hubei, Peoples R China 2.Univ Duisburg Essen, Univ Hosp Essen, Inst Virol, Essen, Germany 3.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Inst Infect & Immunol,Dept Infect Dis, Wuhan 430000, Hubei, Peoples R China 4.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Jia,Li, Ming-Yue,Zhang, Yan-Fang,et al. Dynamic changes in the immunological characteristics of T lymphocytes in surviving patients with severe fever with thrombocytopenia syndrome (SFTS)[J]. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES,2018,70:72-80. |
| APA | Liu, Jia.,Li, Ming-Yue.,Zhang, Yan-Fang.,Xiong, Yan.,Xiong, Shu-E.,...&Zhang, Wen-Jing.(2018).Dynamic changes in the immunological characteristics of T lymphocytes in surviving patients with severe fever with thrombocytopenia syndrome (SFTS).INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES,70,72-80. |
| MLA | Liu, Jia,et al."Dynamic changes in the immunological characteristics of T lymphocytes in surviving patients with severe fever with thrombocytopenia syndrome (SFTS)".INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES 70(2018):72-80. |
入库方式： OAI收割
来源：武汉植物园
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