Effects of starvation on glucose and lipid metabolism in gibel carp (Carassius auratus gibelio var. CAS III)
文献类型：期刊论文
| 作者 | Liu, Haokun1; Xie, Shouqi1; Li, Hongyan1,2; Xu, Wenjie1; Jin, Junyan1; Yang, Yunxia1; Zhu, Xiaoming1; Han, Dong1 |
| 刊名 | AQUACULTURE
 |
| 出版日期 | 2018-11-01 |
| 卷号 | 496页码:166-175 |
| 关键词 | Starvation Plasma metabolites Glucose and lipid metabolism Gibel carp |
| ISSN号 | 0044-8486 |
| DOI | 10.1016/j.aquaculture.2018.07.015 |
| 英文摘要 | Many fish species experience natural periods of starvation; however, mobilization of energy sources may vary. To elucidate the mechanism underlying energy utilization and metabolic adaptation to food deprivation in gibel carp (Carassis auratus gibelio var. CAS III), fish (initial body weight 111.13 +/- 0.65 g) were starved for 0 d, 1 d, 2 d, 7 d, and 21 d, respectively. After seven days of food deprivation, plasma glucose levels significantly decreased, whereas plasma free fatty acids levels significantly increased. Liver glycogen levels in the group starved for 7 d significantly decreased, whereas muscle glycogen levels decreased in the group starved for 21 d, suggesting that glycogen in the liver is first utilized to provide energy than glycogen in the muscle. The transcriptional levels of glucose transporter type 2 (GLUT2) in the liver were upregulated during starvation. No changes in the mRNA levels of glycolytic enzymes such as glucokinase (GK) and 6-phosphofructokinase (6PFK) were observed in the liver. Gluconeogenic potential increased with starvation, possibly for blood glucose homeostasis, as indicated by the enhanced mRNA levels of gluconeogenic enzymes, including glucose-6-phosphatase (G6Pase), fructose 1,6-bisphosphatase (FBPase), and phosphoenolpyruvate carboxykinase (PEPCK). The observation of a decrease in liver triglycerides content and the enhanced expression of hormone-sensitive lipase (HSL) and lipoprotein lipase (LPL) suggests the mobilization of lipid reserve in the liver. Enhanced fatty acid oxidation as indicated by the upregulated mRNA carnitine palmitoyl transferase 1 isoform a (CPT1a) and acyl-CoA oxidase 3 (ACO3) levels in the liver suggests that fatty acids are catabolized to provide energy during starvation. Sterol regulatory element binding protein 1 (SREBP1), ATP citrate lyase (ACLY), acetyl-CoA carboxylase (ACC), and fatty acid synthase (FAS) were downregulated during starvation in both liver and muscle, indicating suppressed lipogenesis. |
| 资助项目 | National Natural Science Foundation of China[31101908] ; National Natural Science Foundation of China[31672670] ; National Natural Science Foundation of China[31602174] ; China Agriculture Research System[CARS-45-09] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA08010405] |
| WOS研究方向 | Fisheries ; Marine & Freshwater Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000440660000020 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/5528]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Jin, Junyan |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Hubei, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Haokun,Xie, Shouqi,Li, Hongyan,et al. Effects of starvation on glucose and lipid metabolism in gibel carp (Carassius auratus gibelio var. CAS III)[J]. AQUACULTURE,2018,496:166-175. |
| APA | Liu, Haokun.,Xie, Shouqi.,Li, Hongyan.,Xu, Wenjie.,Jin, Junyan.,...&Han, Dong.(2018).Effects of starvation on glucose and lipid metabolism in gibel carp (Carassius auratus gibelio var. CAS III).AQUACULTURE,496,166-175. |
| MLA | Liu, Haokun,et al."Effects of starvation on glucose and lipid metabolism in gibel carp (Carassius auratus gibelio var. CAS III)".AQUACULTURE 496(2018):166-175. |
入库方式： OAI收割
来源：武汉植物园
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