A pathogen-derived effector modulates host glucose metabolism by arginine GlcNAcylation of HIF-1 alpha protein
文献类型：期刊论文
| 作者 | Liu, Xing1; Zha, Huangyuan1; Zhang, Dawei1; Fan, Sijia1; Li, Shan3,4; Xiao, Wuhan1,5; Xu, Chenxi1,2 |
| 刊名 | PLOS PATHOGENS
 |
| 出版日期 | 2018-08-01 |
| 卷号 | 14期号:8页码:29 |
| ISSN号 | 1553-7366 |
| DOI | 10.1371/journal.ppat.1007259 |
| 英文摘要 | The essential role of pathogens in host metabolism is widely recognized, yet the mechanisms by which they affect host physiology remain to be fully defined. Here, we found that NIeB, an enteropathogenic Escherichia coli (EPEC) type III secretion system effector known to possess N-acetylglucosamine (GlcNAc) transferase activity, GlcNAcylates HIF-la, a master regulator of cellular O-2 homeostasis. We determined that NIeB-mediated GlcNAcylation at a conserved arginine 18 (Arg18) at the N-terminus of HIF-1 alpha enhanced HIF-1 alpha transcriptional activity, thereby inducing HIF-1 alpha downstream gene expression to alter host glucose metabolism. The arginine transferase activity of NIeB was required for its enhancement of HIF-1 alpha transactivity and the subsequent effect on glucose metabolism in a mouse model of EPEC infection. In addition, HIF-1 alpha acted as a mediator to transact NIeB-mediated induction of glucose metabolism-associated gene expression under hypoxia. Thus, our results further show a causal link between pathogen infection and host glucose metabolism, and we propose a new mechanism by which this occurs. |
| 资助项目 | Strategic Priority Research Program of the Chinese Academy of Sciences[XDA08010208] ; NSFC[91631102] ; NSFC[31830101] ; NSFC[31721005] |
| WOS研究方向 | Microbiology ; Parasitology ; Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000443296800042 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/5646]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Xiao, Wuhan |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Hubei, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Hubei Univ Med, Taihe Hosp, Inst Infect & Immun, Shiyan, Peoples R China 4.Huazhong Agr Univ, Coll Life Sci & Technol, Biomed Ctr, Wuhan, Hubei, Peoples R China 5.Minist Agr, Key Lab Aquaculture Dis Control, Wuhan, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Xing,Zha, Huangyuan,Zhang, Dawei,et al. A pathogen-derived effector modulates host glucose metabolism by arginine GlcNAcylation of HIF-1 alpha protein[J]. PLOS PATHOGENS,2018,14(8):29. |
| APA | Liu, Xing.,Zha, Huangyuan.,Zhang, Dawei.,Fan, Sijia.,Li, Shan.,...&Xu, Chenxi.(2018).A pathogen-derived effector modulates host glucose metabolism by arginine GlcNAcylation of HIF-1 alpha protein.PLOS PATHOGENS,14(8),29. |
| MLA | Liu, Xing,et al."A pathogen-derived effector modulates host glucose metabolism by arginine GlcNAcylation of HIF-1 alpha protein".PLOS PATHOGENS 14.8(2018):29. |
入库方式： OAI收割
来源：武汉植物园
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