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Characterization of grass carp CD40 and CD154 genes and the association between their polymorphisms and resistance to grass carp reovirus

文献类型：期刊论文

作者Zhang, Yong-An2,3,4,5; Nie, Pin2,3,5; Xia, Xiao-Qin5; Li, Shun2,5; Lu, Long-Feng2,5; Zhang, Xiang-Yang1,5; Cui, Zheng-Wei1,5; Chen, Ya-Xin1,5; Lu, Xiao-Bing1,5
刊名FISH & SHELLFISH IMMUNOLOGY
出版日期2018-10-01
卷号81页码:304-308
关键词CD40 CD154 SNP Disease resistance GCRV Grass carp
ISSN号1050-4648
DOI10.1016/j.fsi.2018.07.037
英文摘要In bony fish, CD40 and CD154 are two very important costimulatory molecules involved in T and B cell cooperation in thymus-dependent antibody production. In the current study, we identified the cDNAs of CD40 and CD154 and analyzed their genomic structures in grass carp. Quantitative real-time PCR indicated that the CD40 and CD154 were mainly expressed in immune organs. After challenge with grass carp reovirus (GCRV), these two genes were up-regulated at 72 h in head kidney and spleen. Moreover, seven and five single nucleotide polymorphisms (SNPs) were identified in the CD40 and CD154 respectively. Statistical analysis indicated that three SNPs in the coding region of the CD40 were significantly associated with the resistance of grass carp against GCRV. These results indicated that CD40 and CD154 play important roles in the responses to GCRV in grass carp. The SNP markers in the CD40 associated with the resistance to GCRV may facilitate the disease-resistant breeding of grass carp.
资助项目Chinese Academy of Sciences[XDA08010207] ; National Basic Research Program of China[2014CB138601]
WOS研究方向Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
语种英语
WOS记录号WOS:000443665900035
出版者ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
源URL[http://202.127.146.157/handle/2RYDP1HH/5692]  
专题中国科学院武汉植物园
通讯作者Zhang, Yong-An; Nie, Pin
作者单位1.Univ Chinese Acad Sci, Beijing, Peoples R China
2.Minist Agr, Key Lab Aquaculture Dis Control, Wuhan, Hubei, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
4.Huazhong Agr Univ, State Key Lab Agr Microbiol, Wuhan, Hubei, Peoples R China
5.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Hubei, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Yong-An,Nie, Pin,Xia, Xiao-Qin,et al. Characterization of grass carp CD40 and CD154 genes and the association between their polymorphisms and resistance to grass carp reovirus[J]. FISH & SHELLFISH IMMUNOLOGY,2018,81:304-308.
APA Zhang, Yong-An.,Nie, Pin.,Xia, Xiao-Qin.,Li, Shun.,Lu, Long-Feng.,...&Lu, Xiao-Bing.(2018).Characterization of grass carp CD40 and CD154 genes and the association between their polymorphisms and resistance to grass carp reovirus.FISH & SHELLFISH IMMUNOLOGY,81,304-308.
MLA Zhang, Yong-An,et al."Characterization of grass carp CD40 and CD154 genes and the association between their polymorphisms and resistance to grass carp reovirus".FISH & SHELLFISH IMMUNOLOGY 81(2018):304-308.

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来源：武汉植物园

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