LSECs express functional NOD1 receptors: A role for NOD1 in LSEC maturation-induced T cell immunity in vitro
文献类型：期刊论文
| 作者 | Yang, Dongliang5; Lu, Mengji4; Gong, Feili3; Zheng, Xin5; Liu, Jia5; Lu, Yinping5; Wang, Baoju5; Shi, Chunwei1; Wu, Chunchen2; Feng, Xuemei5 |
| 刊名 | MOLECULAR IMMUNOLOGY
 |
| 出版日期 | 2018-09-01 |
| 卷号 | 101页码:167-175 |
| ISSN号 | 0161-5890 |
| 关键词 | Innate immunity NOD1 ligand LSEC Hepatitis B T cell response |
| DOI | 10.1016/j.molimm.2018.06.002 |
| 英文摘要 | Liver sinusoidal endothelial cells (LSECs) are organ resident APCs capable of antigen presentation and subsequent tolerization of T cells under physiological conditions. In this study, we investigated whether LSEC pretreatment with NOD-like receptor (NLR) agonists can switch the cells from a tolerogenic to an immunogenic state and promote the development of T cell immunity. LSECs constitutively express NOD1, NOD2 and RIPK2. Stimulation of LSECs with DAP induced the activation of NF-kappa B and MAP kinases and upregulated the expression of chemokines (CXCL2/9, CCL2/7/8) and cytokines (IFN-gamma, TNF-alpha and IL-2). Pretreatment of LSECs with DAP induced significantly increased IFN-gamma and IL-2-production by HBV-stimulated CD8(+) T cells primed by DAPtreated LSECs. Consistently, a significant reduction in the HBV DNA and HBsAg level occurred in mice receiving T cells primed by DAP-treated LSECs. MDP stimulation had no impact on LSECs or HBV-stimulated CD8(+) T cells primed with MDP-treated LSECs except for the upregulation of PD-L1. DAP stimulation in vitro could promote LSEC maturation and activate HBV-specific T cell responses. These results are of particular relevance for the regulation of the local innate immune response against HBV infections. |
| 资助项目 | National Natural Science Foundation of China[81461130019] ; National Natural Science Foundation of China[81672022] ; National Natural Science Foundation of China[81001313] ; National Major Science and Technology Project for Infectious Diseases of China[2008ZX10002-011] ; National Major Science and Technology Project for Infectious Diseases of China[2012ZX10004503] ; National Major Science and Technology Project for Infectious Diseases of China[2013ZX10002001-001-006] ; International Science & Technology Cooperation Program of China[2011DFA31030] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Immunology |
| 语种 | 英语 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:000446283700021 |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/5891]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Yang, Dongliang; Lu, Mengji |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Sch Basic Med, Dept Pathogen Biol, Tongji Med Coll, Wuhan, Hubei, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Hubei, Peoples R China 3.Huazhong Univ Sci & Technol, Dept Immunol, Tongji Med Coll, Wuhan, Hubei, Peoples R China 4.Univ Hosp Essen, Inst Virol, Virchowstr 179, D-45147 Essen, Germany 5.Huazhong Univ Sci & Technol, Dept Infect Dis, Union Hosp, Tongji Med Coll, Jiefang Ave 1277, Wuhan 430030, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Dongliang,Lu, Mengji,Gong, Feili,et al. LSECs express functional NOD1 receptors: A role for NOD1 in LSEC maturation-induced T cell immunity in vitro[J]. MOLECULAR IMMUNOLOGY,2018,101:167-175. |
| APA | Yang, Dongliang.,Lu, Mengji.,Gong, Feili.,Zheng, Xin.,Liu, Jia.,...&Huang, Shunmei.(2018).LSECs express functional NOD1 receptors: A role for NOD1 in LSEC maturation-induced T cell immunity in vitro.MOLECULAR IMMUNOLOGY,101,167-175. |
| MLA | Yang, Dongliang,et al."LSECs express functional NOD1 receptors: A role for NOD1 in LSEC maturation-induced T cell immunity in vitro".MOLECULAR IMMUNOLOGY 101(2018):167-175. |
入库方式： OAI收割
来源：武汉植物园
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