Phylogenomic analysis unravels evolution of yellow fever virus within hosts
文献类型：期刊论文
| 作者 | Liu, Di2,3,8; Zeng, Hui10,11; Li, Ang10,11; Bo, Xiaochen9; Liu, Wenjun2,8; Zhang, Fujie7,10,11; Cui, Jie3; Gao, George F.1,2,8; Ma, Juncai8; Xiao, Gengfu3 |
| 刊名 | PLOS NEGLECTED TROPICAL DISEASES
 |
| 出版日期 | 2018-09-01 |
| 卷号 | 12期号:9页码:15 |
| ISSN号 | 1935-2735 |
| DOI | 10.1371/journal.pntd.0006738 |
| 英文摘要 | The yellow fever virus (YFV) recently reemerged in the large outbreaks in Africa and Brazil, and the first imported patients into Asia have recalled the concerns of YFV evolution. Here we show phylogenomics of YFV with serial clinical samples of the 2016 YFV infections. Phylogenetics exhibited that the 2016 strains were close to Angola 1971 strains and only three amino acid changes presented new to other lineages. Deep sequencing of viral genomes discovered 101 intrahost single nucleotide variations (iSNVs) and 234 single nucleotide polymorphisms (SNPs). Analysis of iSNV distribution and mutated allele frequency revealed that the coding regions were under purifying selection. Comparison of the evolutionary rates estimated by iSNV and SNP showed that the intrahost rate was similar to 2.25 times higher than the epidemic rate, and both rates were higher than the long-term YFV substitution rate, as expected. In addition, the result also hinted that short viremia duration of YFV might further hinder the evolution of YFV. |
| 资助项目 | China Ministry of Science and Technology Key Research and Development Program[2016YFC1200804] ; China Ministry of Science and Technology Key Research and Development Program[2016YFC1200805] ; Beijing Municipal Science & Technology Commission[Z161100000116049] ; National Natural Science Foundation of China[91631110] ; National Natural Science Foundation of China[U1435222] ; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support[ZYLX201602NHFPC] ; Beijing Nova program[Z161100004916101] ; Beijing Nova program[Z181100006218114] ; Beijing 215 Project[2015-3-107] ; China National Grand S&T Special Project[2016ZX10004222-010] ; '863' Program[2015AA020108] ; '863' Program[2014AA021501] ; 'Taishan Scholar' project of Shandong Province ; International Fellowship Initiative from CAS ; CAS Pioneer Hundred Talents Program ; National Program for Support of Top-notch Young Professionals |
| WOS研究方向 | Infectious Diseases ; Parasitology ; Tropical Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000446054600019 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/5913]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Liu, Di; Zeng, Hui; Li, Ang |
| 作者单位 | 1.Chinese Ctr Dis Control & Prevent China CDC, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Med Sch, Beijing, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Virol, Wuhan, Hubei, Peoples R China 4.Taishan Med Coll, Inst Pathogen Biol, Tai An, Shandong, Peoples R China 5.Fujian Med Univ, Fuzhou Infect Dis Hosp, Fuzhou, Fujian, Peoples R China 6.Capital Med Univ, Beijing Ditan Hosp, Dept Intens Care Unit, Beijing, Peoples R China 7.Capital Med Univ, Beijing Ditan Hosp, Clin Ctr Infect Dis, Beijing, Peoples R China 8.Chinese Acad Sci, Inst Microbiol, Beijing, Peoples R China 9.Beijing Inst Radiat Med, Beijing, Peoples R China 10.Beijing Key Lab Emerging Infect Dis, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Di,Zeng, Hui,Li, Ang,et al. Phylogenomic analysis unravels evolution of yellow fever virus within hosts[J]. PLOS NEGLECTED TROPICAL DISEASES,2018,12(9):15. |
| APA | Liu, Di.,Zeng, Hui.,Li, Ang.,Bo, Xiaochen.,Liu, Wenjun.,...&Chen, Chen.(2018).Phylogenomic analysis unravels evolution of yellow fever virus within hosts.PLOS NEGLECTED TROPICAL DISEASES,12(9),15. |
| MLA | Liu, Di,et al."Phylogenomic analysis unravels evolution of yellow fever virus within hosts".PLOS NEGLECTED TROPICAL DISEASES 12.9(2018):15. |
入库方式： OAI收割
来源：武汉植物园
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