Characteristic infrared spectroscopic patterns in the protein bands of human breast cancer tissue
文献类型：期刊论文
| 作者 | Eckel, R; Huo, H; Guan, HW; Hu, X; Che, X; Huang, WD |
| 刊名 | vibrational spectroscopy
 |
| 出版日期 | 2001-12-07 |
| 卷号 | 27期号:2页码:165-173 |
| 关键词 | Fourier transform infrared spectroscopy protein bands normal benign and malignant human breast tissues |
| 英文摘要 | infrared (ir) spectra of normal, hyperplasia, fibroadenoma and carcinoma tissues of human breast obtained from 96 patients have been determined and analyzed statistically. several spectral differences were detected in the frequency regions of n-h stretching, amide i, ii and iii bands: (1) the bands in the region 3000-3600cm-1 shifted to lower frequencies for the carcinomatous tissue; (2) the a(3300)/a(3075) absorbance ratio was significantly higher for the fibroadenoma than for the other types of tissues; (3) the frequency of the a-helix amide i band decreased for the malignant tissue, while the corresponding beta -sheet amide i band frequency increased; (4) the a(1657)/a(1635) and a(1553)/a(1540) absorbance ratios were the highest for fibroadenoma and carcinoma tissues; (5) the a(1680)/a(1657) absorbance ratio decreased significantly in the order of normal > hyperplasia > fibroadenoma > carcinoma; (6) the a(1651)/a(1545) absorbance ratio increased slightly for the fibroadenoma and the carcinoma tissues; (7) the bands at 1204 and 1278 cm(-1), assigned to the vibrational modes of the collagen, did not appear in the original spectra as resolved peaks and were distinctly stronger in the deconvoluted spectra of the carcinoma tissue and (8) the a(1657)/a(1204) and a(1657)/a(1278) absorbance ratios, both yielding information on the relative content of collagen, increased in the order of normal < hyperplasia < carcinoma < fibroadenoma. the said differences imply that the information is useful for the diagnosis of breast cancer and malignant breast abnormalities, and may serve as a basis for further studies on conformational changes in tissue proteins during carcinogenesis. (c) 2001 elsevier science b.v. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences ; technology |
| 类目[WOS] | chemistry, analytical ; chemistry, physical ; spectroscopy |
| 研究领域[WOS] | chemistry ; spectroscopy |
| 关键词[WOS] | tuning ft-ir ; spectra ; spectrometry ; cells |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000172407400009 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/91893]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116012, Peoples R China 2.Dalian Med Univ, Affiliated Hosp 1, Dalian 116011, Peoples R China |
| 推荐引用方式 GB/T 7714 | Eckel, R,Huo, H,Guan, HW,et al. Characteristic infrared spectroscopic patterns in the protein bands of human breast cancer tissue[J]. vibrational spectroscopy,2001,27(2):165-173. |
| APA | Eckel, R,Huo, H,Guan, HW,Hu, X,Che, X,&Huang, WD.(2001).Characteristic infrared spectroscopic patterns in the protein bands of human breast cancer tissue.vibrational spectroscopy,27(2),165-173. |
| MLA | Eckel, R,et al."Characteristic infrared spectroscopic patterns in the protein bands of human breast cancer tissue".vibrational spectroscopy 27.2(2001):165-173. |
入库方式： OAI收割
来源：大连化学物理研究所
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