Electrochromatographic evaluation of a silica monolith capillary column for separation of basic pharmaceuticals
文献类型：期刊论文
| 作者 | Xie, CH; Hu, JW; Xiao, H; Su, XY; Dong, J; Tian, RJ; He, ZK; Zou, HF |
| 刊名 | electrophoresis
 |
| 出版日期 | 2005-02-01 |
| 卷号 | 26期号:4-5页码:790-797 |
| 关键词 | basic pharmaceutical electrochromatography retention mechanism silica monolith |
| ISSN号 | 0173-0835 |
| 产权排序 | 1;1 |
| 通讯作者 | 邹汉法 |
| 英文摘要 | a silica-based monolithic capillary column was prepared via a sol-gel process. the continuous skeleton and large through-pore structure were characterized by scanning electron microscopy (sem). the native silica monolith has been successfully employed in the electrochromatographic separation of beta-blockers and alkaloids extracted from traditional chinese medicines (tcms). column efficiencies greater than 250000 plates/m for capillary electrochromatography (cec) separation of basic compounds were obtained. it was observed that retention of basic pharmaceuticals on the silica monolith was mainly contributed by a cation-exchange mechanism. other retention mechanisms including reversed-phase and normal-phase mechanisms and electrophoresis of basic compounds also played a role in separation. a comparison of the differences between cec and capillary zone electrophoresis (cze) separation was also discussed. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | performance liquid-chromatography ; aqueous methanol eluent ; reversed-phase ; stationary-phase ; drugs ; acid ; gel ; enantioseparation |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000227425400007 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/92743]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China 2.Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, CH,Hu, JW,Xiao, H,et al. Electrochromatographic evaluation of a silica monolith capillary column for separation of basic pharmaceuticals[J]. electrophoresis,2005,26(4-5):790-797. |
| APA | Xie, CH.,Hu, JW.,Xiao, H.,Su, XY.,Dong, J.,...&Zou, HF.(2005).Electrochromatographic evaluation of a silica monolith capillary column for separation of basic pharmaceuticals.electrophoresis,26(4-5),790-797. |
| MLA | Xie, CH,et al."Electrochromatographic evaluation of a silica monolith capillary column for separation of basic pharmaceuticals".electrophoresis 26.4-5(2005):790-797. |
入库方式： OAI收割
来源：大连化学物理研究所
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