A new cellular model for in vitro biocompatibility evaluation of microcapsule materials
文献类型：期刊论文
| 作者 | Zhang, H; Sun, L; Wang, W; Ma, XJ; Zhang, X; Tanaka, J; Yu, Y; Tabata, Y |
| 刊名 | asbm6: advanced biomaterials vi
 |
| 出版日期 | 2005 |
| 卷号 | 288-289页码:499-502 |
| 关键词 | biocompatibility in-vitro alginate chitosan |
| 产权排序 | 1;1 |
| 通讯作者 | 马小军 |
| 英文摘要 | fibrosis caused by the host response to long-term transplanted microcapsules and the limitation of traditional l929 cell model for biocompatibility testing inspire the development of an assay of biocompatibility based on macrophage behavior. in this paper, the human monocytic cell line thp-1 was utilized for biocompatibility evaluation of microcapsule materials. the cell viability and secretion of nitric oxide (no) and cytokines served as index of biocompatibility were assayed. it was found that the evaluated microcapsule materials had no effect on the stimulation of no and cytokines secretion, which meant that these materials were biocompatible. furthermore, it suggests the thp-1 cell a convenient in vitro experimental model that might be useful for long-term predictions of material biocompatibility. |
| WOS标题词 | science & technology ; technology |
| 类目[WOS] | engineering, biomedical ; materials science, ceramics ; materials science, biomaterials ; materials science, composites |
| 研究领域[WOS] | engineering ; materials science |
| 关键词[WOS] | islets ; thp-1 |
| 收录类别 | ISTP ; SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000230426600122 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/92781]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Grad Sch, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, H,Sun, L,Wang, W,et al. A new cellular model for in vitro biocompatibility evaluation of microcapsule materials[J]. asbm6: advanced biomaterials vi,2005,288-289:499-502. |
| APA | Zhang, H.,Sun, L.,Wang, W.,Ma, XJ.,Zhang, X.,...&Tabata, Y.(2005).A new cellular model for in vitro biocompatibility evaluation of microcapsule materials.asbm6: advanced biomaterials vi,288-289,499-502. |
| MLA | Zhang, H,et al."A new cellular model for in vitro biocompatibility evaluation of microcapsule materials".asbm6: advanced biomaterials vi 288-289(2005):499-502. |
入库方式： OAI收割
来源：大连化学物理研究所
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