Characterization of interaction property of multicomponents in Chinese Herb with protein by microdialysis combined with HPLC
文献类型：期刊论文
| 作者 | Guo, M; Su, XY; Kong, L; Li, X; Zou, HF |
| 刊名 | analytica chimica acta
 |
| 出版日期 | 2006-01-18 |
| 卷号 | 556期号:1页码:183-188 |
| 关键词 | interaction traditional Chinese medicine protein microdialysis HPLC |
| ISSN号 | 0003-2670 |
| 产权排序 | 1;1 |
| 通讯作者 | 邹汉法 |
| 英文摘要 | interaction of traditional chinese herb rhizoma chuanxiong and protein was studied by microdialysis coupled with high performance liquid chromatography. compounds in rhizoma chuanxiong, such as ferulic acid, senkyunolide a and 3-butylphthalide, were identified by hplc, hplc-ms and uv-vis. microdialysis recoveries and binding degrees of compounds in rhizoma chuanxiong with human serum albumin (hsa) and other human plasma protein were determined: recoveries of microdialysis sampling ranged from 36.7 to 98.4% with r.s.d. below 3.1%; while binding to hsa ranged from 0 to 91.5% (0.3 mm hsa) and from 0 to 93.5% (0.6 mm hsa), respectively. compared with hsa, most of compounds bound to human blood serum more extensively and the results showed that binding of these compounds in rhizoma chuanxiong was influenced by ph. two compounds were found to bind to hsa and human blood serum. their binding degrees were consistent with ferulic acid and 3-butylphthalide, the active compounds in rhizoma chuanoxiong. (c) 2005 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, analytical |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | performance liquid-chromatography ; human serum-albumin ; metal-ions ; binding ; chuanxiong ; identification ; separation ; delivery ; drugs ; ms |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000234724900023 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/93381]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China 2.Dalian Univ Econ & Technol Dev Dist, Dept Chem & Chem Technol, Dalian 116622, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, M,Su, XY,Kong, L,et al. Characterization of interaction property of multicomponents in Chinese Herb with protein by microdialysis combined with HPLC[J]. analytica chimica acta,2006,556(1):183-188. |
| APA | Guo, M,Su, XY,Kong, L,Li, X,&Zou, HF.(2006).Characterization of interaction property of multicomponents in Chinese Herb with protein by microdialysis combined with HPLC.analytica chimica acta,556(1),183-188. |
| MLA | Guo, M,et al."Characterization of interaction property of multicomponents in Chinese Herb with protein by microdialysis combined with HPLC".analytica chimica acta 556.1(2006):183-188. |
入库方式： OAI收割
来源：大连化学物理研究所
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