Pharmacological studies of anti-diarrhoeal activity of Gentianopsis paludosa
文献类型：期刊论文
| 作者 | Wang, HD; Tan, CY; Bai, XF; Du, YG; Lin, BC |
| 刊名 | journal of ethnopharmacology
 |
| 出版日期 | 2006-04-21 |
| 卷号 | 105期号:1-2页码:114-117 |
| 关键词 | Gentianopsis paludosa anti-diarrhoeal isolated ileum |
| 产权排序 | 1;1 |
| 通讯作者 | 王焕弟 |
| 英文摘要 | the pharmacological studies of anti-diarrhoeal activity of gentianopsis paludosa were carried out. the 75% ethanol extract (100-400 mg/kg) of gentianopsis paludosa inhibited castor oil-induced diarrhoea and also reduced gastrointestinal motility in the charcoal meal test in mice. in the rabbit-isolated ileum, the extract showed inhibitory effects not only on its spontaneous contraction, but also on acetylcholine (ach, 0.1 mm)- and kcl (60 mm)-induced contractions. furthermore, the ethanol extract (0.4-0.6 mg/ml) shifted the cacl2 dose-effect curves to the right in a non-competitive manner and significantly reduced the acetylcholine-induced contraction of isolated ileum in ca2+-free solution like verapamil (0.1 mm), which suggest that the extract interferes with ca2+ movement. these results support the traditional use of gentianopsis paludosa in the treatment of diarrhoea. (c) 2005 elsevier ireland ltd. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | plant sciences ; chemistry, medicinal ; integrative & complementary medicine ; pharmacology & pharmacy |
| 研究领域[WOS] | plant sciences ; pharmacology & pharmacy ; integrative & complementary medicine |
| 关键词[WOS] | extract ; ileum ; rats |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000237101300016 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/93693]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Nat Prod & Glycoconjugate Res Grp 1805, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Microfluid Syst Biol, Dalian 116023, Peoples R China 3.Chinese Acad Sci, Grad Sch, Dalian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, HD,Tan, CY,Bai, XF,et al. Pharmacological studies of anti-diarrhoeal activity of Gentianopsis paludosa[J]. journal of ethnopharmacology,2006,105(1-2):114-117. |
| APA | Wang, HD,Tan, CY,Bai, XF,Du, YG,&Lin, BC.(2006).Pharmacological studies of anti-diarrhoeal activity of Gentianopsis paludosa.journal of ethnopharmacology,105(1-2),114-117. |
| MLA | Wang, HD,et al."Pharmacological studies of anti-diarrhoeal activity of Gentianopsis paludosa".journal of ethnopharmacology 105.1-2(2006):114-117. |
入库方式： OAI收割
来源：大连化学物理研究所
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