Biological fingerprinting analysis by liquid chromatography/mass spectrometry for evaluation of DNA structural selectivity of multiple compounds in natural products
文献类型：期刊论文
| 作者 | Su, Xingye; Kong, Liang; Li, Xin; Chen, Xueguo; Guo, Ming; Zou, Hanfa |
| 刊名 | journal of combinatorial chemistry
 |
| 出版日期 | 2006-07-10 |
| 卷号 | 8期号:4页码:544-550 |
| ISSN号 | 1520-4766 |
| 产权排序 | 1;1 |
| 通讯作者 | 邹汉法 |
| 英文摘要 | a method by combination of centrifugal ultrafiltration (cuf) sampling with liquid chromatography-mass spectrometry (lc-ms) analysis was established to evaluate the dna structure and sequence selectivity of the multiple compounds in a small molecule library. the developed method was applied to analyze the extracts of natural products coptis chinensis franch and rheum palmatum (l.). from the obtained biological fingerprinting chromatograms, 7 compounds in c. chinensis franch and 11 in r. palmatum ( l.) were screened out as dna binding agents. most of these compounds were identified by standards and lc-ms analysis after the sample pretreatment with the dna immobilized cartridge. dna structural binding preference of the multiple active compounds in these two extracts was then evaluated simultaneously without purification. |
| WOS标题词 | science & technology ; physical sciences ; life sciences & biomedicine |
| 类目[WOS] | chemistry, applied ; chemistry, medicinal ; chemistry, multidisciplinary |
| 研究领域[WOS] | chemistry ; pharmacology & pharmacy |
| 关键词[WOS] | binding ligands ; rheum-palmatum ; drug design ; anthraquinone ; rhubarb ; microdialysis ; mitoxantrone ; dialysis ; protein ; phase |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000238848900015 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/93877]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China 2.Dalian Univ Technol, Dept Chem & Chem Technol, Dalian 116622, Peoples R China |
| 推荐引用方式 GB/T 7714 | Su, Xingye,Kong, Liang,Li, Xin,et al. Biological fingerprinting analysis by liquid chromatography/mass spectrometry for evaluation of DNA structural selectivity of multiple compounds in natural products[J]. journal of combinatorial chemistry,2006,8(4):544-550. |
| APA | Su, Xingye,Kong, Liang,Li, Xin,Chen, Xueguo,Guo, Ming,&Zou, Hanfa.(2006).Biological fingerprinting analysis by liquid chromatography/mass spectrometry for evaluation of DNA structural selectivity of multiple compounds in natural products.journal of combinatorial chemistry,8(4),544-550. |
| MLA | Su, Xingye,et al."Biological fingerprinting analysis by liquid chromatography/mass spectrometry for evaluation of DNA structural selectivity of multiple compounds in natural products".journal of combinatorial chemistry 8.4(2006):544-550. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。