A preliminary study on fabrication of nanoscale fibrous chitosan membranes in situ by biospecific degradation
文献类型：期刊论文
| 作者 | Ren, Dongwen; Yi, Hongfu; Zhang, Huaan; Xie, Weiyang; Wang, Wei; Ma, Xiaojun |
| 刊名 | journal of membrane science
 |
| 出版日期 | 2006-09-01 |
| 卷号 | 280期号:1-2页码:99-107 |
| 关键词 | chitosan biospecific degradation nanofibers membrane tissue engineering drug delivery |
| 产权排序 | 1;1 |
| 通讯作者 | 马小军 |
| 英文摘要 | a new approach for in situ fabrication of nanoscale fibrous chitosan membrane by biospecific degradation under physiological situation was studied. the chitosan binary blend membranes were fabricated by solvent casting of chitosan solution containing highly deacetylated chitosan (hdc) and moderately deacetylated chitosan (mdc) with different ratio. the biodegradation process was performed in pbs (ph 7.4) containing lysozyme at the temperature of 37 degrees c. experimental results from weight loss, reducing sugar in surrounding media, ft-ir, x-ray diffraction, gel permeation chromatography (gpc) and sem throughout the study showed that the biospecific degradation by lysozyme had removed mdc component selectively. when the ratio of mdc in the binary blend membranes amounted to 0.5, nanoscale domains of hdc and mdc were obtained, and thus a nanoscale fibrous structure was fabricated after biospecific degradation of mdc. this nanofibrous structure and the biospecific degradation of chitosan membranes can have potential advantages and interesting implications in tissue engineering and drug delivery. (c) 2006 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; technology ; physical sciences |
| 类目[WOS] | engineering, chemical ; polymer science |
| 研究领域[WOS] | engineering ; polymer science |
| 关键词[WOS] | n-acetylated chitosans ; polymer nanofibers ; lysozyme ; protein ; chromatography ; compatibility ; matrix ; chitin ; films |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000239472900013 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/97127]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ren, Dongwen,Yi, Hongfu,Zhang, Huaan,et al. A preliminary study on fabrication of nanoscale fibrous chitosan membranes in situ by biospecific degradation[J]. journal of membrane science,2006,280(1-2):99-107. |
| APA | Ren, Dongwen,Yi, Hongfu,Zhang, Huaan,Xie, Weiyang,Wang, Wei,&Ma, Xiaojun.(2006).A preliminary study on fabrication of nanoscale fibrous chitosan membranes in situ by biospecific degradation.journal of membrane science,280(1-2),99-107. |
| MLA | Ren, Dongwen,et al."A preliminary study on fabrication of nanoscale fibrous chitosan membranes in situ by biospecific degradation".journal of membrane science 280.1-2(2006):99-107. |
入库方式： OAI收割
来源：大连化学物理研究所
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